Document Detail


Nano-vectors for the Ocular Delivery of Nucleic Acid-based Therapeutics.
MedLine Citation:
PMID:  21969738     Owner:  NLM     Status:  PubMed-not-MEDLINE    
Abstract/OtherAbstract:
Nucleic acid-based therapeutics have gained a lot of interest for the treatment of diverse ophthalmic pathologies. The first to enter in clinic has been an oligonucleotide, Vitravene(®) for the treatment of cytomegalovirus infection. More recently, research on aptamers for the treatment of age related macular degeneration has led to the development of Macugen(®). Despite intense potential, effective ocular delivery of nucleic acids is a major challenge since therapeutic targets for nucleic acid-based drugs are mainly located in the posterior eye segment, requiring repeated invasive administration. Of late, nanotechnology-based nano-vectors have been developed in order to overcome the drawbacks of viral and other non-viral vectors. The diversity of nano-vectors allows for ease of use, flexibility in application, low-cost of production, higher transfection efficiency and enhanced genomic safety. Using nano-vector strategies, nucleic acids can be delivered either encapsulated or complexed with cationic lipids, polymers or peptides forming sustained release systems, which can be tailored according to the ocular tissue being targeted. The present review focuses on developments and advances in various nano-vectors for the ocular delivery of nucleic acid-based therapeutics, the barriers that such delivery systems face and methods to overcome them.
Authors:
R K Khar; G K Jain; M H Warsi; N Mallick; S Akhter; S A Pathan; F J Ahmad
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Indian journal of pharmaceutical sciences     Volume:  72     ISSN:  1998-3743     ISO Abbreviation:  Indian J Pharm Sci     Publication Date:  2010 Nov 
Date Detail:
Created Date:  2011-10-04     Completed Date:  2011-11-10     Revised Date:  2013-05-29    
Medline Journal Info:
Nlm Unique ID:  7809431     Medline TA:  Indian J Pharm Sci     Country:  India    
Other Details:
Languages:  eng     Pagination:  675-88     Citation Subset:  -    
Affiliation:
Department of Pharmaceutics, Faculty of Pharmacy, Jamia Hamdard, New Delhi - 110 062, India.
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