| Nano-ferrosponges for controlled drug release. | |
| | |
MedLine Citation:
|
PMID: 17644206 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
Magnetic sponge-like hydrogels (ferrosponges) were fabricated by using an in-situ synthesis of magnetic nanoparticles (MNPs) in the presence of various concentrations of gelatin. The resulting ferrosponges show an interconnected nanopore structure which serves as a reservoir to accommodate therapeutic drugs and the nanoporous networks demonstrate magnetic sensitive behavior under the application of magnetic field. The ferrosponges showed high swelling ratios, together with excellent elasticity and hydrophilicity, allow them to response rapidly to an external magnetic stimulation for fast and repeatable swelling-deswelling (or expansion-contractile) operations. The ferrosponges with lower gelatin concentration exhibited good performance on magnetification. Furthermore, drug release from the ferrosponges is relatively magnetic-sensitive and is dominated by its magnetism and associated interaction between the magnetic nanoparticle and the gelatin matrix under an external magnetic field. Higher MNPs concentration in the ferrosponges exhibited higher degree of magnetic sensitive which is due to stronger interparticle forces. By taking these peculiar magnetic sensitive behaviors of the ferrosponges, a novel drug delivery system can be designed for medical uses. |
| | |
Authors:
|
Shang-Hsiu Hu; Ting-Yu Liu; Dean-Mo Liu; San-Yuan Chen |
Related Documents
:
|
12662956 - Metallic artefacts in mr imaging: effects of main field orientation and strength. 17969176 - Measurements of occupational exposure to switched gradient and spatially-varying magnet... 20074366 - Improved methods for magnetic purification of malaria parasites and haemozoin. 18308606 - Technical challenges and opportunities of whole-body magnetic resonance imaging at 3t. 22201536 - Imaging of non- or very subtle contrast-enhancing malignant gliomas with [11c]-methioni... 19063096 - Temporal and geographic patterns in the occurrence and distribution of minke whale (bal... |
Publication Detail:
|
Type: Comparative Study; Journal Article Date: 2007-06-13 |
Journal Detail:
|
Title: Journal of controlled release : official journal of the Controlled Release Society Volume: 121 ISSN: 1873-4995 ISO Abbreviation: J Control Release Publication Date: 2007 Aug |
Date Detail:
|
Created Date: 2007-08-13 Completed Date: 2007-09-20 Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 8607908 Medline TA: J Control Release Country: Netherlands |
Other Details:
|
Languages: eng Pagination: 181-9 Citation Subset: IM |
Affiliation:
|
Department of Materials Sciences and Engineering, National Chiao Tung University, Hsinchu, 300, Taiwan, ROC. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Delayed-Action Preparations
/
administration & dosage,
pharmacokinetics Drug Delivery Systems / methods* Gelatin Sponge, Absorbable / administration & dosage*, pharmacokinetics Hydrogels / administration & dosage, pharmacokinetics Iron Compounds / administration & dosage*, pharmacokinetics Magnetics Nanoparticles / administration & dosage* |
| Chemical | |
Reg. No./Substance:
|
0/Delayed-Action Preparations; 0/Hydrogels; 0/Iron Compounds |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Chitosan and trimethyl chitosan chloride (TMC) as adjuvants for inducing immune responses to ovalbum...
Next Document: A novel use of an in vitro method to predict the in vivo stability of block copolymer based nano-con...