Document Detail

Nano-extrusion: a one-step process for manufacturing of solid nanoparticle formulations directly from the liquid phase.
MedLine Citation:
PMID:  23463263     Owner:  NLM     Status:  MEDLINE    
This paper presents a novel one-step process for converting a liquid stabilized nano-suspension into a solid formulation via hot-melt extrusion combined with an internal devolatilization process (nano-extrusion, NANEX). A polymer (Soluplus®) was fed into the extruder and molten, after which a stable nano-suspension was added via side-feeding devices. The solvent (water) was removed by devolatilization and the polymer solidified at the outlet. The solid material can be tableted or filled in a capsule directly. The results showed that the obtained extrudates comprised nanocrystals in the de-aggregated form, confirming that a solid nano-formulation was prepared. This method is capable of overcoming many of the problems associated with other processes involving solid nano-dosage forms and poses a straightforward approach towards manufacturing such products.
Johannes Khinast; Ramona Baumgartner; Eva Roblegg
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Publication Detail:
Type:  Journal Article     Date:  2013-03-06
Journal Detail:
Title:  AAPS PharmSciTech     Volume:  14     ISSN:  1530-9932     ISO Abbreviation:  AAPS PharmSciTech     Publication Date:  2013 Jun 
Date Detail:
Created Date:  2013-05-29     Completed Date:  2013-10-17     Revised Date:  2014-03-06    
Medline Journal Info:
Nlm Unique ID:  100960111     Medline TA:  AAPS PharmSciTech     Country:  United States    
Other Details:
Languages:  eng     Pagination:  601-4     Citation Subset:  IM    
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MeSH Terms
Chemistry, Pharmaceutical
Dosage Forms
Hot Temperature
Microscopy, Electron, Scanning
Particle Size
Polyethylene Glycols / chemistry
Polyvinyls / chemistry
Solvents / chemistry
Spectrometry, X-Ray Emission
Technology, Pharmaceutical / methods*
Titanium / chemistry
Water / chemistry
Reg. No./Substance:
0/Dosage Forms; 0/Polyethylene Glycols; 0/Polyvinyls; 0/Solvents; 0/polyvinyl caprolactam-polyvinyl acetate-polyethylene glycol graft copolymer; 059QF0KO0R/Water; 15FIX9V2JP/titanium dioxide; D1JT611TNE/Titanium

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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