Document Detail


Nanocapsular dispersion of thymol for enhanced dispersibility and increased antimicrobial effectiveness against Escherichia coli O157:H7 and Listeria monocytogenes in model food systems.
MedLine Citation:
PMID:  23023745     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Essential oils are marginally soluble in water, making it challenging to evenly disperse them in foods and resulting in an increased tendency to bind with food lipids and proteins, resulting in lowered antimicrobial efficacy. In the current study, free and nano-dispersed (ND) thymol were compared in terms of their antimicrobial efficacies against Escherichia coli O157:H7 ATCC 43889 and 43894 and Listeria monocytogenes strains Scott A and 101 in apple cider and 2% reduced-fat milk. Apple cider was adjusted to pHs 5.5 and 3.5, and antimicrobial tests were performed at 0.3-, 0.5-, 0.75-, and 1.0-g/liter thymol concentrations at 35, 32, 25, and 4°C. Overall, 0.5 and 1.0 g/liter thymol in nano-dispersion and along with free thymol were inhibitory and bactericidal, respectively, against bacterial strains under all treatment conditions. At pH 5.5, 0.5 g/liter ND thymol was bacteriostatic against L. monocytogenes and E. coli for up to 48 h. At pH 3.5, L. monocytogenes controls did not survive beyond 12 h but E. coli survived and was inhibited by 0.5 g/liter ND thymol after 12 and 48 h in apple cider. E. coli strains were significantly sensitive to 4°C and pH 3.5 (P < 0.05). When bacteria were tested in 2% reduced-fat milk at 35 or 32°C, ND and free thymol demonstrated inhibition at 4.5 g/liter. Thus, the current technology seems to be promising and novel, enabling thymol-containing nano-dispersions that are not only transparent but also effective against pathogens in food applications, especially in clear beverages.
Authors:
Bhavini Shah; P Michael Davidson; Qixin Zhong
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, Non-P.H.S.     Date:  2012-09-28
Journal Detail:
Title:  Applied and environmental microbiology     Volume:  78     ISSN:  1098-5336     ISO Abbreviation:  Appl. Environ. Microbiol.     Publication Date:  2012 Dec 
Date Detail:
Created Date:  2012-11-09     Completed Date:  2013-04-15     Revised Date:  2013-07-11    
Medline Journal Info:
Nlm Unique ID:  7605801     Medline TA:  Appl Environ Microbiol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  8448-53     Citation Subset:  IM    
Affiliation:
Department of Food Science and Technology, University of Tennessee, Knoxville, Tennessee, USA.
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MeSH Terms
Descriptor/Qualifier:
Animals
Anti-Bacterial Agents / chemistry*,  pharmacokinetics*
Beverages / microbiology
Escherichia coli O157 / drug effects*
Hydrogen-Ion Concentration
Listeria monocytogenes / drug effects*
Microbial Viability / drug effects
Milk / microbiology
Nanostructures*
Temperature
Thymol / chemistry*,  pharmacokinetics*
Time Factors
Chemical
Reg. No./Substance:
0/Anti-Bacterial Agents; 89-83-8/Thymol
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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