Document Detail


Nandrolone treatment decreases the level of rat kidney alpha(1B)-adrenoceptors.
MedLine Citation:
PMID:  12861436     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Abuse of anabolic androgenic steroids (AAS) is associated with serious side effects, such as hypertension and fluid retention. Renal alpha(1)- and alpha(2)-adrenoceptors are implicated in the regulation of blood pressure and fluid balance. In the present study, the levels of renal alpha(1A)-, alpha(1B)-, alpha(2A)- and alpha(2B)-adrenoceptors, and spleen alpha(1B)-adrenoceptors, were quantified in tissue membranes from rats treated with the AAS nandrolone decanoate (15 mg/kg) for 14 days. The radioligands used were [(3)H]-prazosin and [(3)H]-RX821002. The nandrolone treatment caused a 50% reduction of kidney alpha(1B)-adrenoceptors (from 15 fmol/mg protein in control rats to 6.5 fmol/mg protein in treated rats). In contrast, the levels of kidney alpha(1A)-, alpha(2A)- and alpha(2B)-, and spleen alpha(1B)-adrenoceptors were unaffected. These results raise the possibility that a decreased level of kidney alpha(1B)-adrenoceptors may cause some of the effects observed on blood pressure and fluid balance in heavy abuse of AAS.
Authors:
Staffan Uhlén; Jonas Lindblom; Anna Kindlundh; Paul Mugisha; Fred Nyberg
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2003-07-12
Journal Detail:
Title:  Naunyn-Schmiedeberg's archives of pharmacology     Volume:  368     ISSN:  0028-1298     ISO Abbreviation:  Naunyn Schmiedebergs Arch. Pharmacol.     Publication Date:  2003 Aug 
Date Detail:
Created Date:  2003-08-18     Completed Date:  2004-06-23     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0326264     Medline TA:  Naunyn Schmiedebergs Arch Pharmacol     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  91-8     Citation Subset:  IM    
Affiliation:
Department of Pharmaceutical Biosciences, Uppsala University, Box 591 BioMedical Centre, 751 24 Uppsala, Sweden.
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MeSH Terms
Descriptor/Qualifier:
Adrenergic alpha-Antagonists / pharmacology
Anabolic Agents / pharmacology*
Animals
Idazoxan / analogs & derivatives*,  pharmacology
Injections, Intramuscular
Kidney / drug effects*,  metabolism
Ligands
Male
Nandrolone / pharmacology*
Prazosin / pharmacology
Radioligand Assay
Rats
Rats, Sprague-Dawley
Receptors, Adrenergic, alpha-1 / antagonists & inhibitors,  biosynthesis*
Receptors, Adrenergic, alpha-2 / antagonists & inhibitors,  biosynthesis
Spleen / drug effects,  metabolism
Chemical
Reg. No./Substance:
0/Adrenergic alpha-Antagonists; 0/Anabolic Agents; 0/Ligands; 0/Receptors, Adrenergic, alpha-1; 0/Receptors, Adrenergic, alpha-2; 0/adrenergic receptor alpha(1b); 0/adrenergic receptor alpha-2b; 0/receptor, adrenergic, alpha-2A; 102575-24-6/2-methoxyidazoxan; 19216-56-9/Prazosin; 434-22-0/Nandrolone; 79944-58-4/Idazoxan

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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