| Nandrolone and resistance training induce heart remodeling: Role of fetal genes and implications for cardiac pathophysiology. | |
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MedLine Citation:
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PMID: 21889516 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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AIMS: This study was conducted to assess the isolated and combined effects of nandrolone and resistance training on cardiac morphology, function, and mRNA expression of pathological cardiac hypertrophy markers. MAIN METHODS: Wistar rats were randomly divided into four groups and submitted to 6weeks of treatment with nandrolone and/or resistance training. Cardiac parameters were determined by echocardiography. The heart was analyzed for collagen infiltration. Real-time RT-PCR was used to assess the pathological cardiac hypertrophy markers. KEY FINDINGS: Both resistance training and nandrolone induced cardiac hypertrophy. Nandrolone increased the cardiac collagen content, and reduced the cardiac index in non-trained and trained groups, when compared with the respective vehicle-treated groups. Nandrolone reduced the ratio of maximum early to late transmitral flow velocity in non-trained and trained groups, when compared with the respective vehicle-treated groups. Nandrolone reduced the alpha-myosin heavy chain gene expression in both non-trained and trained groups, when compared with the respective vehicle-treated groups. Training reduced the beta-myosin heavy chain gene expression in the groups treated with vehicle and nandrolone. Only the association between training and nandrolone increased the expression of the skeletal alpha-actin gene and atrial natriuretic peptide in the left ventricle. SIGNIFICANCE: This study indicated that nandrolone, whether associated with resistance training or not, induces cardiac hypertrophy, which is associated with enhanced collagen content, re-expression of fetal genes the in left ventricle, and impaired diastolic and systolic function. |
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Authors:
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Ana Paula Tanno; Vander José das Neves; Kaleizu Teodoro Rosa; Tatiana Sousa Cunha; Fernanda Cristina Linarello Giordano; Caroline Morini Calil; Vinicius Guzzoni; Tiago Fernandes; Edilamar Menezes de Oliveira; Pedro Duarte Novaes; Maria Cláudia Irigoyen; Maria José Costa Sampaio Moura; Fernanda Klein Marcondes |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2011-8-17 |
Journal Detail:
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Title: Life sciences Volume: - ISSN: 1879-0631 ISO Abbreviation: - Publication Date: 2011 Aug |
Date Detail:
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Created Date: 2011-9-5 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0375521 Medline TA: Life Sci Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Copyright Information:
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Copyright © 2011. Published by Elsevier Inc. |
Affiliation:
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Department of Physiological Sciences, Piracicaba Dental School, University of Campinas, Piracicaba, SP, Brazil. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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