Document Detail

Nandrolone decanoate impairs exercise-induced cardioprotection: role of antioxidant enzymes.
MedLine Citation:
PMID:  16621517     Owner:  NLM     Status:  MEDLINE    
The beneficial effects of exercise in reducing the incidence of cardiovascular diseases are well known and the abuse of anabolic androgenic steroids (AAS) has been associated to cardiovascular disorders. Previous studies showed that heart protection to ischemic events would be mediated by increasing the antioxidant enzyme activities. Here, we investigated the impact of exercise and high doses of the AAS nandrolone decanoate (DECA), 10 mgkg(-1) body weight during 8 weeks, in cardiac tolerance to ischemic events as well as on the activity of antioxidant enzymes in rats. After a global ischemic event, hearts of control trained (CT) group recovered about 70% of left ventricular developed pressure, whereas DECA trained (DT), control sedentary (CS) and DECA sedentary (DS) animals recovered only about 20%. Similarly, heart infarct size was significantly lower in the CT group compared to animals of the three other groups. The activities of the antioxidant enzymes superoxide dismutase (SOD), glutathione peroxidase (GPx) and glutathione reductase (GR) were significantly higher in CT animals than in the other three groups, whereas catalase activity was not affected in any group. Together, these results indicate that chronic treatment with DECA cause an impairment of exercise induction of antioxidant enzyme activities, leading to a reduced cardioprotection upon ischemic events.
Elen Aguiar Chaves; Pedro Paulo Pereira-Junior; Rodrigo Soares Fortunato; Masako Oya Masuda; Antônio Carlos Campos de Carvalho; Denise Pires de Carvalho; Marcus F Oliveira; José Hamilton Matheus Nascimento
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2006-04-18
Journal Detail:
Title:  The Journal of steroid biochemistry and molecular biology     Volume:  99     ISSN:  0960-0760     ISO Abbreviation:  J. Steroid Biochem. Mol. Biol.     Publication Date:  2006 Jun 
Date Detail:
Created Date:  2006-05-29     Completed Date:  2006-08-14     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  9015483     Medline TA:  J Steroid Biochem Mol Biol     Country:  England    
Other Details:
Languages:  eng     Pagination:  223-30     Citation Subset:  IM    
Instituto de Biofísica Carlos Chagas Filho, Universidade Federal do Rio de Janeiro, Cidade Universitária, Rio de Janeiro, Brazil.
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MeSH Terms
Anabolic Agents / pharmacology*
Cardiotonic Agents / antagonists & inhibitors*
Glutathione Peroxidase / metabolism
Glutathione Reductase / metabolism
Heart / drug effects*
Models, Animal
Myocardial Contraction / drug effects*
Myocardial Infarction / prevention & control*
NADP / metabolism
Nandrolone / analogs & derivatives*,  pharmacology
Physical Conditioning, Animal / physiology*
Rats, Wistar
Reg. No./Substance:
0/Anabolic Agents; 0/Cardiotonic Agents; 360-70-3/nandrolone decanoate; 434-22-0/Nandrolone; 53-59-8/NADP; EC Peroxidase; EC Reductase

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