| Naltrexone's effects on reactivity to alcohol cues among alcoholic men. | |
| | |
MedLine Citation:
|
PMID: 11195999 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
The mechanisms of naltrexone's effects on urges to drink during abstinence are unclear. Naltrexone may suppress either urges to drink specifically or appetitive responses in general. The effects of naltrexone on cue reactivity to alcoholic and sweet nonalcoholic beverages were investigated. Alcohol-dependent men (N = 53) in treatment received naltrexone (50 mg) or placebo. Four hours later, they received baseline assessment, exposure to fruit juice, and exposure to their usual alcoholic beverage in 3-min trials. Naltrexone reduced urge to drink and self-reported attention to the alcohol cues, not at the initial exposure but after repeated exposures to alcohol cues. Naltrexone reduced negative affect across baseline and alcohol trials. No effects of naltrexone on responses to the nonalcoholic appetitive beverage cues were found, suggesting that general appetite suppression does not mediate the effects of naltrexone on urges. |
| | |
Authors:
|
D J Rohsenow; P M Monti; K E Hutchison; R M Swift; S M Colby; G B Kaplan |
Related Documents
:
|
11583769 - Health in a 24-h society. 17990119 - Using correlational evidence to select youth for prevention programming. 15050679 - Using collaterals to validate self-reports of problem drinkers: any impact on client at... 14574069 - Employment frustration and alcohol abuse/dependence among labor migrants in california. 18803289 - Smoking and serum ca19-9 levels according to lewis and secretor genotypes. 6841939 - Tax-deductible alcohol: an issue of public health policy and prevention strategy. 3671819 - Sensory reinforcement of head turning with nonambulatory, profoundly mentally retarded ... 20127089 - The development of an ecosystem services framework for south east queensland. 17671279 - A longitudinal study of the use of mental health services by persons with serious menta... |
Publication Detail:
|
Type: Clinical Trial; Journal Article; Randomized Controlled Trial; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
|
Title: Journal of abnormal psychology Volume: 109 ISSN: 0021-843X ISO Abbreviation: J Abnorm Psychol Publication Date: 2000 Nov |
Date Detail:
|
Created Date: 2001-01-23 Completed Date: 2001-02-22 Revised Date: 2009-11-11 |
Medline Journal Info:
|
Nlm Unique ID: 0034461 Medline TA: J Abnorm Psychol Country: United States |
Other Details:
|
Languages: eng Pagination: 738-42 Citation Subset: IM |
Affiliation:
|
Research Service, Providence Veterans Affairs Medical Center, Providence, Rhode Island. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Adult Alcohol Drinking / adverse effects, psychology Alcoholism / psychology, rehabilitation* Arousal / drug effects Attention / drug effects Cues Humans Male Middle Aged Motivation* Naltrexone / therapeutic use* Substance Withdrawal Syndrome / diagnosis*, psychology Taste / drug effects |
| Grant Support | |
ID/Acronym/Agency:
|
AA07459/AA/NIAAA NIH HHS |
| Chemical | |
Reg. No./Substance:
|
16590-41-3/Naltrexone |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Borderline personality: traits and disorder.
Next Document: The paradox of normal neuropsychological function in schizophrenia.