Document Detail


Naltrexone's effects on reactivity to alcohol cues among alcoholic men.
MedLine Citation:
PMID:  11195999     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The mechanisms of naltrexone's effects on urges to drink during abstinence are unclear. Naltrexone may suppress either urges to drink specifically or appetitive responses in general. The effects of naltrexone on cue reactivity to alcoholic and sweet nonalcoholic beverages were investigated. Alcohol-dependent men (N = 53) in treatment received naltrexone (50 mg) or placebo. Four hours later, they received baseline assessment, exposure to fruit juice, and exposure to their usual alcoholic beverage in 3-min trials. Naltrexone reduced urge to drink and self-reported attention to the alcohol cues, not at the initial exposure but after repeated exposures to alcohol cues. Naltrexone reduced negative affect across baseline and alcohol trials. No effects of naltrexone on responses to the nonalcoholic appetitive beverage cues were found, suggesting that general appetite suppression does not mediate the effects of naltrexone on urges.
Authors:
D J Rohsenow; P M Monti; K E Hutchison; R M Swift; S M Colby; G B Kaplan
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Publication Detail:
Type:  Clinical Trial; Journal Article; Randomized Controlled Trial; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Journal of abnormal psychology     Volume:  109     ISSN:  0021-843X     ISO Abbreviation:  J Abnorm Psychol     Publication Date:  2000 Nov 
Date Detail:
Created Date:  2001-01-23     Completed Date:  2001-02-22     Revised Date:  2009-11-11    
Medline Journal Info:
Nlm Unique ID:  0034461     Medline TA:  J Abnorm Psychol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  738-42     Citation Subset:  IM    
Affiliation:
Research Service, Providence Veterans Affairs Medical Center, Providence, Rhode Island.
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MeSH Terms
Descriptor/Qualifier:
Adult
Alcohol Drinking / adverse effects,  psychology
Alcoholism / psychology,  rehabilitation*
Arousal / drug effects
Attention / drug effects
Cues
Humans
Male
Middle Aged
Motivation*
Naltrexone / therapeutic use*
Substance Withdrawal Syndrome / diagnosis*,  psychology
Taste / drug effects
Grant Support
ID/Acronym/Agency:
AA07459/AA/NIAAA NIH HHS
Chemical
Reg. No./Substance:
16590-41-3/Naltrexone

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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