Document Detail

Naltrexone treatment produces dose-related effects on food and water intake but daily alcohol consumption is not affected.
MedLine Citation:
PMID:  18681987     Owner:  NLM     Status:  MEDLINE    
There is evidence that naltrexone, an opioid antagonist, affects alcohol and food consumption. Though food intake is inherently involved when naltrexone effects on alcohol consumption have been studied, the differential effect of this opioid antagonist on both food and alcohol intake has not yet been reported. The present study analyzed the effect of a single daily dose of naltrexone on alcohol, food and water intake when these substances were available on a continuous basis. Wistar male rats were treated with s.c. injections of either naltrexone (2 or 10 mg/kg/day/rat) or a saline solution, 0.2 ml/day/rat for 7 days. This period was followed by a lapse of 7 days with no treatment (PT period), and this sequence of naltrexone or saline treatment followed by a period without treatment was repeated four times. Neither 2 mg/kg nor 10 mg/kg of naltrexone affected alcohol consumption, though the higher dose of naltrexone (10 mg/kg) increased food intake with respect to both the PT periods and the saline group and decreased water consumption with respect to the corresponding PT periods. Naltrexone at 2 mg/kg produced a decrease in food intake but only with respect to the PT periods. These results suggest that the effects of a single dose of naltrexone on alcohol consumption may not be evident when 24-h access to alcohol is assessed; however, naltrexone may produce different dose-related effects on food and water intake, suggesting that they may be mediated by distinct opioid system mechanisms.
Jorge Juárez; Eliana Barrios De Tomasi
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Nutritional neuroscience     Volume:  11     ISSN:  1476-8305     ISO Abbreviation:  Nutr Neurosci     Publication Date:  2008 Aug 
Date Detail:
Created Date:  2008-08-06     Completed Date:  2009-01-29     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  100892202     Medline TA:  Nutr Neurosci     Country:  England    
Other Details:
Languages:  eng     Pagination:  183-92     Citation Subset:  IM    
Laboratorio de Farmacología y Conducta, Instituto de Neurociencias, CUCBA, Universidad de Guadalajara, Guadalajara, Jalisco, México.
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MeSH Terms
Alcohol Drinking*
Dose-Response Relationship, Drug
Drinking / drug effects*
Eating / drug effects*
Naltrexone / administration & dosage*
Narcotic Antagonists / administration & dosage*
Rats, Wistar
Reg. No./Substance:
0/Narcotic Antagonists; 16590-41-3/Naltrexone

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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