| Naltrexone for the treatment of alcoholism: clinical findings, mechanisms of action, and pharmacogenetics. | |
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MedLine Citation:
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PMID: 20201811 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Naltrexone is an opioid receptor antagonist with established efficacy, albeit moderate, for the treatment of alcohol dependence. This manuscript provides a critical review of the literature on naltrexone as a pharmacotherapy for alcoholism by covering the following areas: (a) clinical findings from treatment studies; (b) pharmacokinetics and safety data; (c) medication compliance and persistence; and (d) neurobiological and biobehavioral mechanisms of action of naltrexone for the indication of alcohol dependence. This review will then focus on the emerging literature on naltrexone pharmacogenetics, which has the potential to identify responders on the basis of genetic variation and to use genetic tools to individualize the use of this medication. Limitations and future directions in the research and practice of naltrexone for alcoholism are also outlined. |
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Authors:
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Lara A Ray; Pauline F Chin; Karen Miotto |
Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Review |
Journal Detail:
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Title: CNS & neurological disorders drug targets Volume: 9 ISSN: 1996-3181 ISO Abbreviation: CNS Neurol Disord Drug Targets Publication Date: 2010 Mar |
Date Detail:
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Created Date: 2010-03-05 Completed Date: 2010-06-14 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101269155 Medline TA: CNS Neurol Disord Drug Targets Country: United Arab Emirates |
Other Details:
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Languages: eng Pagination: 13-22 Citation Subset: IM |
Affiliation:
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Department of Psychology, University of California Los Angeles, CA 90095-1563, USA. lararay@psych.ucla.edu |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Alcohol-Induced Disorders, Nervous System
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drug therapy*,
genetics,
physiopathology Alcoholism / drug therapy*, genetics, physiopathology Brain / drug effects, metabolism, physiopathology Brain Chemistry / drug effects, genetics Genetic Predisposition to Disease / genetics Humans Naltrexone / pharmacology*, therapeutic use* Narcotic Antagonists / pharmacology, therapeutic use Receptors, Opioid, mu / drug effects, genetics, metabolism |
| Chemical | |
Reg. No./Substance:
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0/Narcotic Antagonists; 0/OPRM1 protein, human; 0/Receptors, Opioid, mu; 16590-41-3/Naltrexone |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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