Document Detail

Naloxone and the ventilatory response to exercise in man.
MedLine Citation:
PMID:  3780706     Owner:  NLM     Status:  MEDLINE    
Endogenous opiate peptides are known to exert a depressant action on ventilation (VE), and their plasma levels have been shown to be elevated during a variety of exercise protocols. We investigated whether they might modulate the control of the hyperpnea of short-term constant-load (CLE) and incremental (IE) cycle-ergometer exercise. Four healthy subjects performed CLE tests at ca. 80% of the anaerobic threshold (theta an) for 5 min following a period of unloaded pedaling, and IE tests (10 or 20 W min-1) to the limit of tolerance. Normal saline (3 ml) or the opiate antagonist naloxone (1.2 mg in 3 ml) were administered intravenously prior to each test. Naloxone elicited no discernible effect on VE, alveolar gas tensions, or heart rate throughout the entire range of work rates; neither were theta an nor the maximum work rate affected. It is concluded that, for short-term exercise ranging in intensity from moderate to severe, the role played by endogenous opiate peptides in the control of the exercise hyperpnea appears to be negligible in man.
C Griffis; R D Kaufman; S A Ward
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  European journal of applied physiology and occupational physiology     Volume:  55     ISSN:  0301-5548     ISO Abbreviation:  Eur J Appl Physiol Occup Physiol     Publication Date:  1986  
Date Detail:
Created Date:  1987-01-20     Completed Date:  1987-01-20     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  0410266     Medline TA:  Eur J Appl Physiol Occup Physiol     Country:  GERMANY, WEST    
Other Details:
Languages:  eng     Pagination:  624-9     Citation Subset:  IM; S    
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MeSH Terms
Endorphins / physiology*
Heart Rate / drug effects
Naloxone / diagnostic use*,  pharmacology
Physical Exertion*
Pulmonary Gas Exchange / drug effects
Respiration* / drug effects
Reg. No./Substance:
0/Endorphins; 465-65-6/Naloxone

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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