| Naloxone reduces food intake in humans. | |
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MedLine Citation:
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PMID: 4048359 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Hypotheses generated from animal studies that the endogenous opioid system is an important modulator of food intake suggest that blockade of the system in humans should affect eating behavior. To assess this hypothesis, seven normal volunteers were given 2 mg/kg naloxone or placebo on separate days in a double-blind, random but balanced cross-over experimental design. Compared to placebo, naloxone was found to reduce significantly total food intake from preselected prepared trays served 2.75 and 7.75 hours after drug administration (p less than 0.02). The reduction was considerable (28%), and although the magnitude varied greatly among individuals, reduction occurred in each. This reduced food intake was not accompanied by a demonstrable alteration of the volunteers' perceptions of their hunger. Further cautious experimental investigation of naloxone's effects during long-term administration and in patients with eating disorders is warranted in light of its apparent effect of reducing food intake in humans while not decreasing their satiety. |
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Authors:
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M R Cohen; R M Cohen; D Pickar; D L Murphy |
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Publication Detail:
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Type: Clinical Trial; Journal Article; Randomized Controlled Trial |
Journal Detail:
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Title: Psychosomatic medicine Volume: 47 ISSN: 0033-3174 ISO Abbreviation: Psychosom Med Publication Date: 1985 Mar-Apr |
Date Detail:
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Created Date: 1985-10-28 Completed Date: 1985-10-28 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 0376505 Medline TA: Psychosom Med Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 132-8 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Dietary Carbohydrates / administration & dosage Dietary Fats / administration & dosage Dietary Proteins / administration & dosage Double-Blind Method Eating / drug effects* Energy Intake / drug effects Female Humans Hunger / drug effects Male Middle Aged Naloxone / pharmacology* |
| Chemical | |
Reg. No./Substance:
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0/Dietary Carbohydrates; 0/Dietary Fats; 0/Dietary Proteins; 465-65-6/Naloxone |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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