Document Detail

Naloxone reduces food intake in humans.
MedLine Citation:
PMID:  4048359     Owner:  NLM     Status:  MEDLINE    
Hypotheses generated from animal studies that the endogenous opioid system is an important modulator of food intake suggest that blockade of the system in humans should affect eating behavior. To assess this hypothesis, seven normal volunteers were given 2 mg/kg naloxone or placebo on separate days in a double-blind, random but balanced cross-over experimental design. Compared to placebo, naloxone was found to reduce significantly total food intake from preselected prepared trays served 2.75 and 7.75 hours after drug administration (p less than 0.02). The reduction was considerable (28%), and although the magnitude varied greatly among individuals, reduction occurred in each. This reduced food intake was not accompanied by a demonstrable alteration of the volunteers' perceptions of their hunger. Further cautious experimental investigation of naloxone's effects during long-term administration and in patients with eating disorders is warranted in light of its apparent effect of reducing food intake in humans while not decreasing their satiety.
M R Cohen; R M Cohen; D Pickar; D L Murphy
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Publication Detail:
Type:  Clinical Trial; Journal Article; Randomized Controlled Trial    
Journal Detail:
Title:  Psychosomatic medicine     Volume:  47     ISSN:  0033-3174     ISO Abbreviation:  Psychosom Med     Publication Date:    1985 Mar-Apr
Date Detail:
Created Date:  1985-10-28     Completed Date:  1985-10-28     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0376505     Medline TA:  Psychosom Med     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  132-8     Citation Subset:  IM    
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MeSH Terms
Dietary Carbohydrates / administration & dosage
Dietary Fats / administration & dosage
Dietary Proteins / administration & dosage
Double-Blind Method
Eating / drug effects*
Energy Intake / drug effects
Hunger / drug effects
Middle Aged
Naloxone / pharmacology*
Reg. No./Substance:
0/Dietary Carbohydrates; 0/Dietary Fats; 0/Dietary Proteins; 465-65-6/Naloxone

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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