Document Detail

Naloxone potentiates inotropic but not chronotropic effects of isoproterenol in vitro.
MedLine Citation:
PMID:  8453747     Owner:  NLM     Status:  MEDLINE    
Tachycardia often limits the usefulness of conventional beta-adrenergic inotropic therapy; therefore, a compound possessing positive inotropic but not chronotropic properties would be useful. These experiments determined the inotropic and chronotropic properties of naloxone in spontaneously contracting guinea pig atria and electrically paced papillary muscles in the presence and absence of isoproterenol. In atria naloxone exhibited no significant intrinsic inotropic properties. In the presence of isoproterenol, naloxone increased contractility in spontaneously contracting atria and electrically paced ventricular tissues by 11% and 79% respectively, without any significant change in contraction rate. Since naloxone potentiated the inotropic but not chronotropic effects of isoproterenol, it may be a useful adjunct to conventional beta-adrenergic therapy where an inotropic but not chronotropic effect is desired.
R B Lechner
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Circulatory shock     Volume:  39     ISSN:  0092-6213     ISO Abbreviation:  Circ. Shock     Publication Date:  1993 Mar 
Date Detail:
Created Date:  1993-04-22     Completed Date:  1993-04-22     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  0414112     Medline TA:  Circ Shock     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  226-30     Citation Subset:  IM    
Department of Anesthesiology, University of Virginia, Charlottesville 22908.
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MeSH Terms
Cardiac Pacing, Artificial
Dose-Response Relationship, Drug
Drug Synergism
Guinea Pigs
Heart / drug effects
Heart Atria
Heart Rate / drug effects*
Isoproterenol / pharmacology*
Myocardial Contraction / drug effects*
Naloxone / pharmacology*
Papillary Muscles / drug effects
Stimulation, Chemical
Reg. No./Substance:
465-65-6/Naloxone; 7683-59-2/Isoproterenol

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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