Document Detail

Naloxone pharmacokinetics in the newborn.
MedLine Citation:
PMID:  7387817     Owner:  NLM     Status:  MEDLINE    
1 Plasma naloxone levels were determined by RIA over a period of 6--36 h in three groups of neonates, (1) those given 35 microgram i.v. (n = 6), (2) those given 70 microgram i.v. (n = 6) and (3) those given 200 microgram i.m. (n = 17) naloxone HCl within 1 min of birth. 2 After intravenous administration of 35 and 70 microgram of naloxone peak levels of 4--15 ng/ml and 9--20 ng/ml respectively were reached in 5--40 min and the mean plasma half-life after both doses was 3.1 +/- 0.5 h. 3 Peak levels of 7--35 ng/ml were reached 0.5 to 2 h after intramuscular administration of 200 microgram. The fall in concentration after this was consistently biphasic with the levels declining rapidly between one and four hours and then slowly from four hours onwards. 4 Plasma levels at 24--36 h after i.m. administration were as high as they were 4 h after i.v. administration of 35 microgram and this may account for the prolonged duration of action when this route is used.
T A Moreland; J E Brice; C H Walker; A C Parija
Related Documents :
22394807 - 85 effect of follicular aspiration just prior to ovulation on corpus luteum characteris...
12667387 - Thrombosis and its significance after experimental pulmonary thromboembolism.
2325017 - Endocrine changes during pregnancy, parturition and the early post-partum period in the...
10089217 - Calcidiol and pth levels in women attending an osteoporosis program.
25031827 - Diagnostic values of plasma, fresh and frozen urine nt-probnp in heart failure patients.
10942177 - Cyp2d6*10 alleles are not the determinant of the plasma haloperidol concentrations in a...
Publication Detail:
Type:  Clinical Trial; Journal Article; Randomized Controlled Trial    
Journal Detail:
Title:  British journal of clinical pharmacology     Volume:  9     ISSN:  0306-5251     ISO Abbreviation:  Br J Clin Pharmacol     Publication Date:  1980 Jun 
Date Detail:
Created Date:  1980-09-28     Completed Date:  1980-09-28     Revised Date:  2009-11-18    
Medline Journal Info:
Nlm Unique ID:  7503323     Medline TA:  Br J Clin Pharmacol     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  609-12     Citation Subset:  IM    
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Infant, Newborn*
Injections, Intramuscular
Injections, Intravenous
Naloxone / administration & dosage,  blood,  metabolism*
Time Factors
Reg. No./Substance:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Effect of therapeutic dosage of lithium on the heart.
Next Document:  Changes in concanavalin A-mediated agglutination of hormone-dependent mouse mammary tumour cells dur...