Document Detail


Naloxone pharmacokinetics in the newborn.
MedLine Citation:
PMID:  7387817     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
1 Plasma naloxone levels were determined by RIA over a period of 6--36 h in three groups of neonates, (1) those given 35 microgram i.v. (n = 6), (2) those given 70 microgram i.v. (n = 6) and (3) those given 200 microgram i.m. (n = 17) naloxone HCl within 1 min of birth. 2 After intravenous administration of 35 and 70 microgram of naloxone peak levels of 4--15 ng/ml and 9--20 ng/ml respectively were reached in 5--40 min and the mean plasma half-life after both doses was 3.1 +/- 0.5 h. 3 Peak levels of 7--35 ng/ml were reached 0.5 to 2 h after intramuscular administration of 200 microgram. The fall in concentration after this was consistently biphasic with the levels declining rapidly between one and four hours and then slowly from four hours onwards. 4 Plasma levels at 24--36 h after i.m. administration were as high as they were 4 h after i.v. administration of 35 microgram and this may account for the prolonged duration of action when this route is used.
Authors:
T A Moreland; J E Brice; C H Walker; A C Parija
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Publication Detail:
Type:  Clinical Trial; Journal Article; Randomized Controlled Trial    
Journal Detail:
Title:  British journal of clinical pharmacology     Volume:  9     ISSN:  0306-5251     ISO Abbreviation:  Br J Clin Pharmacol     Publication Date:  1980 Jun 
Date Detail:
Created Date:  1980-09-28     Completed Date:  1980-09-28     Revised Date:  2009-11-18    
Medline Journal Info:
Nlm Unique ID:  7503323     Medline TA:  Br J Clin Pharmacol     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  609-12     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Half-Life
Humans
Infant, Newborn*
Injections, Intramuscular
Injections, Intravenous
Kinetics
Naloxone / administration & dosage,  blood,  metabolism*
Radioimmunoassay
Time Factors
Chemical
Reg. No./Substance:
465-65-6/Naloxone
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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