Document Detail

Naloxone-induced suppression of food intake in normal and hypothalamic obese rats.
MedLine Citation:
PMID:  538063     Owner:  NLM     Status:  MEDLINE    
Intraperitoneal injections of naloxone hydrochloride (1, 2, 4, and 8 mg/kg) suppressed food intake in both normal and hypothalamic obese rats maintained on a 4-hr per day feeding schedule. The decrease in feeding was more pronounced in the animals with ventromedial hypothalamic lesions. Appetitively motivated feeding, i.e., the consumption of sweetened milk under nondeprived conditions, was also suppressed by naloxone, but there was no reliable difference between groups. It is concluded that opiate receptors located in the ventromedial hypothalamus are not essential for the effects of opiate agonists and antagonists on feeding behavior.
B M King; F X Castellanos; A J Kastin; M C Berzas; M D Mauk; G A Olson; R D Olson
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Pharmacology, biochemistry, and behavior     Volume:  11     ISSN:  0091-3057     ISO Abbreviation:  Pharmacol. Biochem. Behav.     Publication Date:  1979 Dec 
Date Detail:
Created Date:  1980-05-30     Completed Date:  1980-05-30     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  0367050     Medline TA:  Pharmacol Biochem Behav     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  729-32     Citation Subset:  IM    
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MeSH Terms
Feeding Behavior / drug effects*
Food Deprivation
Hypothalamus / anatomy & histology,  physiology*
Naloxone / pharmacology*
Obesity / physiopathology,  psychology*
Reg. No./Substance:

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