| Naloxone-induced suppression of food intake in normal and hypothalamic obese rats. | |
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MedLine Citation:
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PMID: 538063 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Intraperitoneal injections of naloxone hydrochloride (1, 2, 4, and 8 mg/kg) suppressed food intake in both normal and hypothalamic obese rats maintained on a 4-hr per day feeding schedule. The decrease in feeding was more pronounced in the animals with ventromedial hypothalamic lesions. Appetitively motivated feeding, i.e., the consumption of sweetened milk under nondeprived conditions, was also suppressed by naloxone, but there was no reliable difference between groups. It is concluded that opiate receptors located in the ventromedial hypothalamus are not essential for the effects of opiate agonists and antagonists on feeding behavior. |
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Authors:
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B M King; F X Castellanos; A J Kastin; M C Berzas; M D Mauk; G A Olson; R D Olson |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Pharmacology, biochemistry, and behavior Volume: 11 ISSN: 0091-3057 ISO Abbreviation: Pharmacol. Biochem. Behav. Publication Date: 1979 Dec |
Date Detail:
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Created Date: 1980-05-30 Completed Date: 1980-05-30 Revised Date: 2003-11-14 |
Medline Journal Info:
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Nlm Unique ID: 0367050 Medline TA: Pharmacol Biochem Behav Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 729-32 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Feeding Behavior / drug effects* Female Food Deprivation Hypothalamus / anatomy & histology, physiology* Naloxone / pharmacology* Obesity / physiopathology, psychology* Rats |
| Chemical | |
Reg. No./Substance:
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465-65-6/Naloxone |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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