| Naloxone-induced electrographic seizures in the primate. | |
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MedLine Citation:
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PMID: 6770398 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Electrographic seizure activity was recorded shortly following naxolone injections in artificially ventilated, methadone-treated stump-tailed macaques. Plasma-methadone concentrations prior to seizure activity were many times higher than those that have produced respiratory depression and death in nonventilated monkeys. The duration of seizure activity was clearly related to the dose of naloxone. Naloxone was without epileptogenic properties in animals that had not been pretreated with methadone. The results suggest that methadone and naloxone have additive epileptogenic properties when high blood levels of methadone are achieved in the artificially ventilated primate. Naloxone was devoid of antagonistic properties with respect to opiate-induced electroencephalographic spiking activity. |
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Authors:
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E W Snyder; D E Shearer; E C Beck; R E Dustmann |
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Publication Detail:
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Type: Journal Article; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: Psychopharmacology Volume: 67 ISSN: 0033-3158 ISO Abbreviation: Psychopharmacology (Berl.) Publication Date: 1980 |
Date Detail:
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Created Date: 1980-08-25 Completed Date: 1980-08-25 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 7608025 Medline TA: Psychopharmacology (Berl) Country: GERMANY, WEST |
Other Details:
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Languages: eng Pagination: 211-4 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Blood Pressure / drug effects Body Temperature / drug effects Drug Interactions Electrocardiography Electroencephalography Female Haplorhini Macaca Male Methadone / pharmacology Naloxone / pharmacology* Seizures / chemically induced*, physiopathology Time Factors |
| Chemical | |
Reg. No./Substance:
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465-65-6/Naloxone; 76-99-3/Methadone |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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