Document Detail

Naloxone-induced electrographic seizures in the primate.
MedLine Citation:
PMID:  6770398     Owner:  NLM     Status:  MEDLINE    
Electrographic seizure activity was recorded shortly following naxolone injections in artificially ventilated, methadone-treated stump-tailed macaques. Plasma-methadone concentrations prior to seizure activity were many times higher than those that have produced respiratory depression and death in nonventilated monkeys. The duration of seizure activity was clearly related to the dose of naloxone. Naloxone was without epileptogenic properties in animals that had not been pretreated with methadone. The results suggest that methadone and naloxone have additive epileptogenic properties when high blood levels of methadone are achieved in the artificially ventilated primate. Naloxone was devoid of antagonistic properties with respect to opiate-induced electroencephalographic spiking activity.
E W Snyder; D E Shearer; E C Beck; R E Dustmann
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Psychopharmacology     Volume:  67     ISSN:  0033-3158     ISO Abbreviation:  Psychopharmacology (Berl.)     Publication Date:  1980  
Date Detail:
Created Date:  1980-08-25     Completed Date:  1980-08-25     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7608025     Medline TA:  Psychopharmacology (Berl)     Country:  GERMANY, WEST    
Other Details:
Languages:  eng     Pagination:  211-4     Citation Subset:  IM    
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MeSH Terms
Blood Pressure / drug effects
Body Temperature / drug effects
Drug Interactions
Methadone / pharmacology
Naloxone / pharmacology*
Seizures / chemically induced*,  physiopathology
Time Factors
Reg. No./Substance:
465-65-6/Naloxone; 76-99-3/Methadone

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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