| Naloxone in cardiac arrest with suspected opioid overdoses. | |
MedLine Citation:
|
PMID: 19913979 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
INTRODUCTION: Naloxone's use in cardiac arrest has been of recent interest, stimulated by conflicting results in both human case reports and animal studies demonstrating antiarrhythmic and positive ionotropic effects. We hypothesized that naloxone administration during cardiac arrest, in suspected opioid overdosed patients, is associated with a change in cardiac rhythm. METHODS: From a database of 32,544 advanced life support (ALS) emergency medical dispatches between January 2003 and December 2007, a retrospective chart review was completed of patients receiving naloxone in cardiac arrest. Forty-two patients in non-traumatic cardiac arrest were identified. Each patient received naloxone because of suspicion by a paramedic of acute opioid use. RESULTS: Fifteen of the 36 (42%) (95% confidence interval [CI]: 26-58) patients in cardiac arrest who received naloxone in the pre-hospital setting had an improvement in electrocardiogram (EKG) rhythm. Of the participants who responded to naloxone, 47% (95% CI: 21-72) (19% [95% CI: 7-32] of all study subjects) demonstrated EKG rhythm changes immediately following the administration of naloxone. DISCUSSION: Although we cannot support the routine use of naloxone during cardiac arrest, we recommend its administration with any suspicion of opioid use. Due to low rates of return of spontaneous circulation and survival during cardiac arrest, any potential intervention leading to rhythm improvement is a reasonable treatment modality. |
Authors:
|
Matthew D Saybolt; Scott M Alter; Frank Dos Santos; Diane P Calello; Kevin O Rynn; Daniel A Nelson; Mark A Merlin |
Related Documents
:
|
14975039 - Time-dependent interventions. 16563599 - Empiric tenecteplase is associated with increased return of spontaneous circulation and... 1389719 - Emergency coronary artery surgery after refractory cardiac arrest: a single centre expe... 8760549 - Ventricular fibrillation in the patient with blunt trauma: not always exsanguination. 7600399 - Percutaneous central venous access for resuscitation in trauma. 7609749 - Blunt impact to the chest leading to sudden death from cardiac arrest during sports act... 15225119 - Evaluation of ischemic heart disease with cardiac magnetic resonance and computed tomog... 11176019 - Double-chambered right ventricle in an adult patient. 14975039 - Time-dependent interventions. |
Publication Detail:
|
Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2009-11-13 |
Journal Detail:
|
Title: Resuscitation Volume: 81 ISSN: 1873-1570 ISO Abbreviation: Resuscitation Publication Date: 2010 Jan |
Date Detail:
|
Created Date: 2010-02-01 Completed Date: 2010-05-04 Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 0332173 Medline TA: Resuscitation Country: Ireland |
Other Details:
|
Languages: eng Pagination: 42-6 Citation Subset: IM |
Copyright Information:
|
Copyright 2009 Elsevier Ireland Ltd. All rights reserved. |
Affiliation:
|
UMDNJ-Robert Wood Johnson Medical School, Piscataway, NJ, USA. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Adult Aged Confidence Intervals Electrocardiography Emergency Medical Services / organization & administration Female Heart Arrest / chemically induced*, drug therapy* Humans Male Middle Aged Naloxone / therapeutic use* Narcotic Antagonists / therapeutic use* Narcotics / poisoning* Overdose Retrospective Studies Treatment Outcome |
| Chemical | |
Reg. No./Substance:
|
0/Narcotic Antagonists; 0/Narcotics; 465-65-6/Naloxone |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Hypocalcemia following resuscitation from cardiac arrest revisited.
Next Document: Predictors of adopting therapeutic hypothermia for post-cardiac arrest patients among Canadian emerg...