Document Detail

Naloxone efficacy in bladder rehabilitation of spinal cord injury patients.
MedLine Citation:
PMID:  3586156     Owner:  NLM     Status:  MEDLINE    
Naloxone has been reported to facilitate detrusor activity by blocking the inhibitory action of the enkephalins. We tested the urodynamic effects of intravenous naloxone (0.4 to 0.8 mg.) in 15 patients with spinal cord injury via rapid fill carbon dioxide cystometry and perineal electromyography. Fourteen patients had suprasacral lesions (3 complete), while 1 had an incomplete lower cord lesion. The average interval from injury was 4.2 months. Most of the patients were managed with intermittent catheterization and most had chronic bacteriuria. Initially, 10 patients had detrusor areflexia and 5 had detrusor hyperreflexia (2 with dyssynergia). Of the 15 patients 14 had no neuropathic condition as noted on baseline electromyography. After naloxone injection no significant cystometrographic changes occurred but 11 patients (73 per cent) had decreased electromyographic activity. The vesicourethral pattern of the 2 patients with dyssynergia did not change after naloxone, even though the electromyographic response decreased in both. The patients showed no other effects of the naloxone administration. Contrary to other studies, naloxone seemed to diminish pelvic floor (electromyographic) activity but it did not change bladder (cystometrographic) function during bladder rehabilitation of spinal cord injury patients.
J S Wheeler; C J Robinson; D J Culkin; B A Nemchausky
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  The Journal of urology     Volume:  137     ISSN:  0022-5347     ISO Abbreviation:  J. Urol.     Publication Date:  1987 Jun 
Date Detail:
Created Date:  1987-06-29     Completed Date:  1987-06-29     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0376374     Medline TA:  J Urol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1202-5     Citation Subset:  AIM; IM    
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MeSH Terms
Enkephalins / antagonists & inhibitors
Middle Aged
Naloxone / therapeutic use*
Spinal Cord Injuries / complications*
Urinary Bladder / physiopathology
Urinary Bladder, Neurogenic / drug therapy*,  etiology
Urinary Catheterization
Urodynamics / drug effects
Reg. No./Substance:
0/Enkephalins; 465-65-6/Naloxone

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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