Document Detail

Naloxone blocks that portion of feeding driven by sweet taste in food-restricted rats.
MedLine Citation:
PMID:  7840328     Owner:  NLM     Status:  MEDLINE    
We evaluated the potency of naloxone on intake of normal and sweet chow in food-deprived and schedule-fed rats. We found that naloxone's anorectic potency was dependent on the type of chow presented to the rats and the deprivation schedule utilized to stimulate food intake. In 24-h and 48-h deprived rats, naloxone decreased intake of normal rat chow at doses ranging from 0.3 to 3 mg/kg. In chronically deprived rats (80% of normal body wt), these doses of naloxone failed to decrease intake of normal chow. Rats eating sweet chow ate more when energy deprived and were more sensitive than rats eating normal chow to naloxone-induced limitations in food intake, both in acute and chronic food-deprived groups. Thus naloxone decreased intake of sweet chow much more effectively than normal chow even when rats were chronically food deprived. We also found that an extremely low dose of naloxone (0.03 mg/kg) decreased intake of sweet chow by almost 50% in satiated rats.
A S Levine; D T Weldon; M Grace; J P Cleary; C J Billington
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  The American journal of physiology     Volume:  268     ISSN:  0002-9513     ISO Abbreviation:  Am. J. Physiol.     Publication Date:  1995 Jan 
Date Detail:
Created Date:  1995-02-27     Completed Date:  1995-02-27     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  0370511     Medline TA:  Am J Physiol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  R248-52     Citation Subset:  IM    
Research Service, Veterans Affairs Medical Center, Minneapolis 55417.
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MeSH Terms
Dose-Response Relationship, Drug
Feeding Behavior / drug effects,  physiology*
Food Deprivation*
Naloxone / pharmacology*
Random Allocation
Rats, Sprague-Dawley
Sweetening Agents*
Time Factors
Grant Support
Reg. No./Substance:
0/Sweetening Agents; 465-65-6/Naloxone; 57-50-1/Sucrose

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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