| Nalidixic acid inhibition of post-ultraviolet recovery in Escherichia coli K-12: requirement for recBC function. | |
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MedLine Citation:
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PMID: 791087 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Various repair-deficient mutants of Escherichia coli K-12 were tested for the impairment of post-ultraviolet survival by nalidixic acid. These studies have shown that the target of this nalidixic acid effect is dictated by the recB and recC genes and may be due to the binding of nalidixic acid to exonuclease V. Furthermore, this effect cannot be correlated with either recombination proficiency or excision repair alone. |
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Authors:
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M A Purdy; K L Yeilding |
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Publication Detail:
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Type: Journal Article; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: Antimicrobial agents and chemotherapy Volume: 10 ISSN: 0066-4804 ISO Abbreviation: Antimicrob. Agents Chemother. Publication Date: 1976 Jul |
Date Detail:
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Created Date: 1976-12-23 Completed Date: 1976-12-23 Revised Date: 2009-11-18 |
Medline Journal Info:
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Nlm Unique ID: 0315061 Medline TA: Antimicrob Agents Chemother Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 182-4 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Dose-Response Relationship, Radiation Escherichia coli / drug effects*, radiation effects* Mutation Nalidixic Acid / pharmacology* Recombination, Genetic* Ultraviolet Rays |
| Chemical | |
Reg. No./Substance:
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389-08-2/Nalidixic Acid |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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