| Naked dense bodies provoke depression. | |
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MedLine Citation:
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PMID: 20980589 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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At presynaptic active zones (AZs), the frequently observed tethering of synaptic vesicles to an electron-dense cytomatrix represents a process of largely unknown functional significance. Here, we identified a hypomorphic allele, brpnude, lacking merely the last 1% of the C-terminal amino acids (17 of 1740) of the active zone protein Bruchpilot. In brpnude, electron-dense bodies were properly shaped, though entirely bare of synaptic vesicles. While basal glutamate release was unchanged, paired-pulse and sustained stimulation provoked depression. Furthermore, rapid recovery following sustained release was slowed. Our results causally link, with intramolecular precision, the tethering of vesicles at the AZ cytomatrix to synaptic depression. |
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Authors:
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Stefan Hallermann; Robert J Kittel; Carolin Wichmann; Annika Weyhersmüller; Wernher Fouquet; Sara Mertel; David Owald; Stefan Eimer; Harald Depner; Martin Schwärzel; Stephan J Sigrist; Manfred Heckmann |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: The Journal of neuroscience : the official journal of the Society for Neuroscience Volume: 30 ISSN: 1529-2401 ISO Abbreviation: J. Neurosci. Publication Date: 2010 Oct |
Date Detail:
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Created Date: 2010-10-28 Completed Date: 2010-11-30 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8102140 Medline TA: J Neurosci Country: United States |
Other Details:
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Languages: eng Pagination: 14340-5 Citation Subset: IM |
Affiliation:
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Carl-Ludwig-Institute of Physiology, Medical Faculty, University of Leipzig, 04103 Leipzig, Germany. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Base Sequence Calcium Channels / metabolism Cytoplasm / metabolism Drosophila Drosophila Proteins / genetics* Electric Stimulation Electrophysiology Kinetics Larva Microscopy, Electron Molecular Sequence Data Mutation Patch-Clamp Techniques Presynaptic Terminals / physiology* Synaptic Vesicles / genetics*, physiology* |
| Chemical | |
Reg. No./Substance:
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0/Calcium Channels; 0/Drosophila Proteins; 0/bruchpilot protein, Drosophila |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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