Document Detail

Naked dense bodies provoke depression.
MedLine Citation:
PMID:  20980589     Owner:  NLM     Status:  MEDLINE    
At presynaptic active zones (AZs), the frequently observed tethering of synaptic vesicles to an electron-dense cytomatrix represents a process of largely unknown functional significance. Here, we identified a hypomorphic allele, brpnude, lacking merely the last 1% of the C-terminal amino acids (17 of 1740) of the active zone protein Bruchpilot. In brpnude, electron-dense bodies were properly shaped, though entirely bare of synaptic vesicles. While basal glutamate release was unchanged, paired-pulse and sustained stimulation provoked depression. Furthermore, rapid recovery following sustained release was slowed. Our results causally link, with intramolecular precision, the tethering of vesicles at the AZ cytomatrix to synaptic depression.
Stefan Hallermann; Robert J Kittel; Carolin Wichmann; Annika Weyhersmüller; Wernher Fouquet; Sara Mertel; David Owald; Stefan Eimer; Harald Depner; Martin Schwärzel; Stephan J Sigrist; Manfred Heckmann
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  The Journal of neuroscience : the official journal of the Society for Neuroscience     Volume:  30     ISSN:  1529-2401     ISO Abbreviation:  J. Neurosci.     Publication Date:  2010 Oct 
Date Detail:
Created Date:  2010-10-28     Completed Date:  2010-11-30     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8102140     Medline TA:  J Neurosci     Country:  United States    
Other Details:
Languages:  eng     Pagination:  14340-5     Citation Subset:  IM    
Carl-Ludwig-Institute of Physiology, Medical Faculty, University of Leipzig, 04103 Leipzig, Germany.
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MeSH Terms
Base Sequence
Calcium Channels / metabolism
Cytoplasm / metabolism
Drosophila Proteins / genetics*
Electric Stimulation
Microscopy, Electron
Molecular Sequence Data
Patch-Clamp Techniques
Presynaptic Terminals / physiology*
Synaptic Vesicles / genetics*,  physiology*
Reg. No./Substance:
0/Calcium Channels; 0/Drosophila Proteins; 0/bruchpilot protein, Drosophila

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