| Naive T cell homeostasis: from awareness of space to a sense of place. | |
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MedLine Citation:
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PMID: 19935802 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The peripheral naive T cell pool is fairly stable in number, diversity and functional competence in the absence of vigorous immune responses. However, this apparent tranquility is not an intrinsic property of T cells but involves continuous tuning of the T cell pool composition by homeostatic signals. In the past decade, studies have revealed that naive T cells rely on combinatorial signals from self-peptide-MHC complexes and interleukin-7 for their physical and functional maintenance. Competition for these factors dictates T cell 'space'. In addition, recent studies show that these and other homeostatic factors are offered to T cells on stromal cell networks, which also serve to guide T cell trafficking in secondary lymphoid organs. Such findings suggest the importance of 'place' in the perception and integration of homeostatic cues for the maintenance and functional tuning of the naive T cell pool. |
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Authors:
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Kensuke Takada; Stephen C Jameson |
Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Review |
Journal Detail:
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Title: Nature reviews. Immunology Volume: 9 ISSN: 1474-1741 ISO Abbreviation: Nat. Rev. Immunol. Publication Date: 2009 Dec |
Date Detail:
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Created Date: 2009-11-25 Completed Date: 2009-12-22 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101124169 Medline TA: Nat Rev Immunol Country: England |
Other Details:
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Languages: eng Pagination: 823-32 Citation Subset: IM |
Affiliation:
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Center for Immunology, Department of Laboratory Medicine and Pathology, University of Minnesota Medical School, Minneapolis, Minnesota 55455, USA. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Chemotaxis, Leukocyte / immunology* Homeostasis / immunology* Humans T-Lymphocytes / immunology* |
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