| Nailfold capillaroscopy abnormalities correlate with cutaneous and visceral involvement in systemic sclerosis patients. | |
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MedLine Citation:
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PMID: 19474777 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: The aim of this study was to correlate quantitative and semiquantitative nailfold capillaroscopy (NFC) parameters with the extent of cutaneous and visceral involvement in systemic sclerosis (SSc) patients. METHODS: The presence of clinical and serological alterations was evaluated retrospectively and correlated with NFC findings (number of capillary loops/mm, vascular deletion score and number of enlarged and giant capillary loops). For evaluation of disease extension five manifestations were analyzed: finger pad lesions, skin involvement, esophageal involvement, interstitial lung disease, and pulmonary hypertension. RESULTS: There were 105 NFC examinations in 92 patients, 13 of whom were evaluated at two different time points. Patients with diffuse cutaneous SSc had a higher vascular deletion score than patients with limited cutaneous SSc, sine scleroderma SSc, and overlap syndrome (1.67+/-0.91 vs 0.99+/-0.82; p=0.0005). Modified Rodnan's skin score correlated positively with capillary deletion, evaluated by the vascular deletion score and the number of capillary loops/mm (p<0.001 and p=0.012; respectively). Patients with three or more involved tracts presented lower number of capillary loops/mm (8.00+/-1.69 vs 9.23+/-1.31 capillary loops/mm; p=0.025) and a higher vascular deletion score (1.41+/-0.95 vs 0.73+/-0.76; p=0.027) when compared to patients with less than three affected tracts. Vascular deletion score was significantly higher in patients with anti-Scl-70 antibodies that in patients without anti-Scl-70 antibodies (p=0.02). CONCLUSIONS: NFC abnormalities correlated positively with the diffuse form of SSc, the degree of cutaneous involvement, the number of affected tracts, and the presence of anti-Scl-70 antibodies. |
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Authors:
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Lucy T Sato; Cristiane Kayser; Luís E C Andrade |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Acta reumatológica portuguesa Volume: 34 ISSN: 0303-464X ISO Abbreviation: Acta Reumatol Port Publication Date: 2009 Apr-Jun |
Date Detail:
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Created Date: 2009-05-28 Completed Date: 2009-08-13 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0431702 Medline TA: Acta Reumatol Port Country: Portugal |
Other Details:
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Languages: eng Pagination: 219-27 Citation Subset: IM |
Affiliation:
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Rheumatology Division, Universidade Federal de São Paulo (UNIFESP), CEP 04023-062, São Paulo, Brazil. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Aged Female Humans Male Microscopic Angioscopy* Middle Aged Retrospective Studies Scleroderma, Systemic / complications*, pathology Skin Diseases / etiology*, pathology* Viscera* Young Adult |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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