Document Detail


Nailfold capillaroscopy abnormalities correlate with cutaneous and visceral involvement in systemic sclerosis patients.
MedLine Citation:
PMID:  19474777     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVE: The aim of this study was to correlate quantitative and semiquantitative nailfold capillaroscopy (NFC) parameters with the extent of cutaneous and visceral involvement in systemic sclerosis (SSc) patients. METHODS: The presence of clinical and serological alterations was evaluated retrospectively and correlated with NFC findings (number of capillary loops/mm, vascular deletion score and number of enlarged and giant capillary loops). For evaluation of disease extension five manifestations were analyzed: finger pad lesions, skin involvement, esophageal involvement, interstitial lung disease, and pulmonary hypertension. RESULTS: There were 105 NFC examinations in 92 patients, 13 of whom were evaluated at two different time points. Patients with diffuse cutaneous SSc had a higher vascular deletion score than patients with limited cutaneous SSc, sine scleroderma SSc, and overlap syndrome (1.67+/-0.91 vs 0.99+/-0.82; p=0.0005). Modified Rodnan's skin score correlated positively with capillary deletion, evaluated by the vascular deletion score and the number of capillary loops/mm (p<0.001 and p=0.012; respectively). Patients with three or more involved tracts presented lower number of capillary loops/mm (8.00+/-1.69 vs 9.23+/-1.31 capillary loops/mm; p=0.025) and a higher vascular deletion score (1.41+/-0.95 vs 0.73+/-0.76; p=0.027) when compared to patients with less than three affected tracts. Vascular deletion score was significantly higher in patients with anti-Scl-70 antibodies that in patients without anti-Scl-70 antibodies (p=0.02). CONCLUSIONS: NFC abnormalities correlated positively with the diffuse form of SSc, the degree of cutaneous involvement, the number of affected tracts, and the presence of anti-Scl-70 antibodies.
Authors:
Lucy T Sato; Cristiane Kayser; Luís E C Andrade
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Acta reumatológica portuguesa     Volume:  34     ISSN:  0303-464X     ISO Abbreviation:  Acta Reumatol Port     Publication Date:    2009 Apr-Jun
Date Detail:
Created Date:  2009-05-28     Completed Date:  2009-08-13     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0431702     Medline TA:  Acta Reumatol Port     Country:  Portugal    
Other Details:
Languages:  eng     Pagination:  219-27     Citation Subset:  IM    
Affiliation:
Rheumatology Division, Universidade Federal de São Paulo (UNIFESP), CEP 04023-062, São Paulo, Brazil.
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MeSH Terms
Descriptor/Qualifier:
Adult
Aged
Female
Humans
Male
Microscopic Angioscopy*
Middle Aged
Retrospective Studies
Scleroderma, Systemic / complications*,  pathology
Skin Diseases / etiology*,  pathology*
Viscera*
Young Adult

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