Document Detail

Nailfold capillaroscopy abnormalities as predictors of mortality in patients with systemic sclerosis.
MedLine Citation:
PMID:  23324736     Owner:  NLM     Status:  Publisher    
OBJECTIVES: Peripheral microangiopathy is a hallmark of systemic sclerosis (SSc) and can be early detected by nailfold capillaroscopy (NFC). This study aimed to examine whether more severe peripheral microangiopathy at NFC are predictive factor for death in SSc patients. METHODS: 135 SSc patients who performed NFC between June 2001 and July 2009 were included. The following NFC parameters were evaluated: number of capillary loops/mm, avascular score (scored from 0 to 3), and number of enlarged and giant capillary loops. Univariate and multivariate regression models were used to analyse the association of mortality with NFC and clinical parameters. RESULTS: At the time of the analysis (August 2010), 123 patients were alive, and 12 were dead. By univariate analysis, male gender, forced vital capacity <75% predicted, higher number of giant capillary loops, and an avascular score >1.5 on NFC were associated with a significantly increase risk of death. By multivariate analysis, an avascular score >1.5 was the only independent predictor of death (hazard ratio 2.265). Survival rates from diagnosis at 1, 5 and 10 years were lower in patients with avascular score >1.5 (97%, 86%, and 59%, respectively) compared with those with avascular score ≤1.5 (97%, 97%, and 91% respectively) (p=0.009 by log rank test). CONCLUSIONS: Avascular scores higher than 1.5 at NFC was an independent predictor of death in SSc, suggesting that NFC can be useful for predicting SSc outcome.
Cristiane Kayser; Juliana Y Sekiyama; Lucas C Próspero; Cintia Z Camargo; Luis E C Andrade
Related Documents :
20508046 - Association of systemic health and functional outcomes with changes in hard exudates as...
17090876 - Combination therapy of intravitreal triamcinolone and photodynamic therapy with vertepo...
24507986 - Impact of tricuspid regurgitation after redo valvular surgery on survival in patients w...
24216316 - Long-term follow-up of stentless prosthesis.
25143506 - A comparison of concentric and eccentric glenospheres in reverse shoulder arthroplasty:...
22795096 - Fertility outcome of infertile women with adenomyosis treated with the combination of a...
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2013-1-16
Journal Detail:
Title:  Clinical and experimental rheumatology     Volume:  -     ISSN:  0392-856X     ISO Abbreviation:  Clin. Exp. Rheumatol.     Publication Date:  2013 Jan 
Date Detail:
Created Date:  2013-1-17     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8308521     Medline TA:  Clin Exp Rheumatol     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Rheumatology Division, Universidade Federal de São Paulo, São Paulo, Brazil.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Quantitative in silico Analysis of Organic Modifier Effect on Retention in Reversed-Phase Liquid Chr...
Next Document:  Auditory and speech performance in deaf children with deaf parents after cochlear implant.