Document Detail

Naftopidil vs silodosin in medical expulsive therapy for ureteral stones: a randomized controlled study in Japanese male patients.
MedLine Citation:
PMID:  21917021     Owner:  NLM     Status:  MEDLINE    
The aim of the present study was to compare the efficacy of the selective α(1D) -adrenoceptor antagonist naftopidil and the selective α(1A) -adrenoceptor antagonist silodosin (as an example) in the management of ureteral stones in Japanese male patients. A total of 74 patients with symptomatic ≤ 10 mm ureteral stones were enrolled in a prospective study and randomized into two groups: Group 1 received 50 mg naftopidil daily, whereas Group 2 received 8 mg silodosin daily. Patients were followed-up for up to 6 weeks. The primary endpoint was stone expulsion rate and secondary endpoints were stone expulsion time, the rate of interventions, such as transurethral ureterolithotripsy, extracorporeal shock wave lithotripsy, or ureteral stenting, and side effects. There were no significant differences between the two groups with respect to age, stone size, and location. The stone expulsion rate was 61% and 84% in the naftopidil and silodosin groups, respectively (P = 0.038). No significant differences were noted in stone expulsion time or the rate of interventions between the two groups. The findings suggest that α(1A)-adrenoceptor blockade was clinically superior for stone expulsion our study population.
Yasuo Tsuzaka; Hisashi Matsushima; Tomoyuki Kaneko; Tsuyoshi Yamaguchi; Yukio Homma
Publication Detail:
Type:  Comparative Study; Journal Article; Randomized Controlled Trial     Date:  2011-09-14
Journal Detail:
Title:  International journal of urology : official journal of the Japanese Urological Association     Volume:  18     ISSN:  1442-2042     ISO Abbreviation:  Int. J. Urol.     Publication Date:  2011 Nov 
Date Detail:
Created Date:  2011-11-04     Completed Date:  2012-03-30     Revised Date:  2013-05-22    
Medline Journal Info:
Nlm Unique ID:  9440237     Medline TA:  Int J Urol     Country:  Australia    
Other Details:
Languages:  eng     Pagination:  792-5     Citation Subset:  IM    
Copyright Information:
© 2011 The Japanese Urological Association.
Department of Urology, Tokyo Metropolitan Police Hospital, Japan.
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MeSH Terms
Adrenergic alpha-Antagonists / therapeutic use*
Indoles / therapeutic use*
Middle Aged
Naphthalenes / therapeutic use*
Piperazines / therapeutic use*
Time Factors
Ureteral Calculi / drug therapy*
Reg. No./Substance:
0/Adrenergic alpha-Antagonists; 0/Indoles; 0/Naphthalenes; 0/Piperazines; CUZ39LUY82/silodosin; R9PHW59SFN/naftopidil
Comment In:
Int J Urol. 2012 Aug;19(8):792; author reply 792-3   [PMID:  22435593 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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