Document Detail

Nabumetone compared with indomethacin in the treatment of osteoarthritis in general practice.
MedLine Citation:
PMID:  1474536     Owner:  NLM     Status:  MEDLINE    
In a double blind, randomized, parallel group study, 197 patients with osteoarthritis (OA) received nabumetone (1000 mg/day) or indomethacin (75 mg/day) for 6 weeks and doses could be doubled. Doubling the dose resulted in a 100 or 67% increase in pain relief with nabumetone or indomethacin, respectively. Significantly more patients experienced at least 1 severe adverse event with indomethacin than with nabumetone. With nabumetone, the incidence of adverse events did not increase with dose. However, with the increase in dose, the incidence of all adverse events and gastrointestinal events increased in indomethacin treated patients. Nabumetone was as effective as indomethacin for the treatment of OA. However, significantly fewer nabumetone treated patients experienced severe adverse events and the frequency of events did not increase with dose.
W K Carle; A G Wade; D C Kill; M Poland
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Publication Detail:
Type:  Clinical Trial; Comparative Study; Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  The Journal of rheumatology. Supplement     Volume:  36     ISSN:  0380-0903     ISO Abbreviation:  J Rheumatol Suppl     Publication Date:  1992 Nov 
Date Detail:
Created Date:  1993-02-02     Completed Date:  1993-02-02     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7806058     Medline TA:  J Rheumatol Suppl     Country:  CANADA    
Other Details:
Languages:  eng     Pagination:  58-62     Citation Subset:  IM    
Community Pharmacology Services, Clydebank, Scotland.
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MeSH Terms
Anti-Inflammatory Agents, Non-Steroidal / therapeutic use
Butanones / administration & dosage,  adverse effects,  therapeutic use*
Dose-Response Relationship, Drug
Family Practice / methods
Indomethacin / administration & dosage,  adverse effects,  therapeutic use*
Middle Aged
Osteoarthritis / drug therapy*,  physiopathology
Treatment Outcome
Reg. No./Substance:
0/Anti-Inflammatory Agents, Non-Steroidal; 0/Butanones; 42924-53-8/nabumetone; 53-86-1/Indomethacin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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