Document Detail


NaCl potentiates human fibrocyte differentiation.
MedLine Citation:
PMID:  23029177     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Excessive NaCl intake is associated with a variety of fibrosing diseases such as renal and cardiac fibrosis. This association has been attributed to increased blood pressure as the result of high NaCl intake. However, studies in patients with high NaCl intake and fibrosis reveal a connection between NaCl intake and fibrosis that is independent of blood pressure. We find that increasing the extracellular concentration of NaCl to levels that may occur in human blood after high-salt intake can potentiate, in serum-free culture conditions, the differentiation of freshly-isolated human monocytes into fibroblast-like cells called fibrocytes. NaCl affects the monocytes directly during their adhesion. Potassium chloride and sodium nitrate also potentiate fibrocyte differentiation. The plasma protein Serum Amyloid P (SAP) inhibits fibrocyte differentiation. High levels of extracellular NaCl change the SAP Hill coefficient from 1.7 to 0.8, and cause a four-fold increase in the concentration of SAP needed to inhibit fibrocyte differentiation by 95%. Together, our data suggest that NaCl potentiates fibrocyte differentiation. NaCl-increased fibrocyte differentiation may thus contribute to NaCl-increased renal and cardiac fibrosis.
Authors:
Nehemiah Cox; Darrell Pilling; Richard H Gomer
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2012-09-18
Journal Detail:
Title:  PloS one     Volume:  7     ISSN:  1932-6203     ISO Abbreviation:  PLoS ONE     Publication Date:  2012  
Date Detail:
Created Date:  2012-10-02     Completed Date:  2013-03-28     Revised Date:  2013-07-11    
Medline Journal Info:
Nlm Unique ID:  101285081     Medline TA:  PLoS One     Country:  United States    
Other Details:
Languages:  eng     Pagination:  e45674     Citation Subset:  IM    
Affiliation:
Department of Biology, Texas A&M University, College Station, TX, USA.
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MeSH Terms
Descriptor/Qualifier:
Cell Differentiation / drug effects,  physiology*
Gluconates / pharmacology
Humans
Monocytes / cytology*,  drug effects
Nitrates / pharmacology
Serum Amyloid P-Component / physiology
Sodium Chloride / pharmacology*
Chemical
Reg. No./Substance:
0/Gluconates; 0/Nitrates; 0/Serum Amyloid P-Component; 7647-14-5/Sodium Chloride; 8M4L3H2ZVZ/sodium nitrate; R4R8J0Q44B/gluconic acid
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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