| Na+-independent exchange of amino acids in Ehrlich cells. | |
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MedLine Citation:
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PMID: 6850413 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Many hydrophilic amino acids are transported via exchange by the Na+-independent L system in the Ehrlich cells. However, this exchange is measurable only at relative high concentrations of the small hydrophilic amino acids. Whereas leucine saturated this transport system at 0.2 mM, with threonine, serine, or alanine the system was below saturation at 30 mM. All amino acids capable of exchanging showed similar EA values (congruent to 20 X 10(3) cal X mol-1, 1 cal = 4.1868 J) and maximum velocities. Depending on the temperature, the apparent Km values for different amino acids differed by one or two orders of magnitude. These data suggest that for the small hydrophilic amino acids, the relatively slow rate of transport is due to the unfavorable Km values. |
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Authors:
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R M Johnstone |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Canadian journal of biochemistry and cell biology = Revue canadienne de biochimie et biologie cellulaire Volume: 61 ISSN: 0714-7511 ISO Abbreviation: Can. J. Biochem. Cell Biol. Publication Date: 1983 Apr |
Date Detail:
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Created Date: 1983-07-15 Completed Date: 1983-07-15 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 8302763 Medline TA: Can J Biochem Cell Biol Country: CANADA |
Other Details:
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Languages: eng Pagination: 165-70 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Amino Acids
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metabolism* Animals Carcinoma, Ehrlich Tumor / metabolism* Kinetics Mice Sodium / metabolism* Structure-Activity Relationship Temperature |
| Chemical | |
Reg. No./Substance:
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0/Amino Acids; 7440-23-5/Sodium |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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