Document Detail

Na /H+ exchange inhibitor cariporide: effects on respiratory dysfunction after cardiopulmonary bypass.
MedLine Citation:
PMID:  15072253     Owner:  NLM     Status:  MEDLINE    
The purpose of the present study was to evaluate the potential of the Na+/H+ exchange inhibitor cariporide to protect the lung from injury after cardiopulmonary bypass (CPB). In a randomized placebo-controlled study, 16 pigs were subjected to CPB for 75 min. Administration of vehicle or cariporide (bolus 180 mg, 40 mg/hour) began 30 min pre-CPB and was continued throughout the protocol. The alveolo-arterial O2-gradient (AaDO2), the pulmonary shunt (Qs/Qt), the compliance (Cpl), haemodynamic variables and glycerol and water content in lung tissue were measured 10 min before and up to 180 min post-CPB. All animals in the control versus 75% in the cariporide group survived the experiment. At 5 and 60 min post-CPB, the mean AaDO2 and at 5, 60 and 180 min post-CPB, the mean pulmonary vascular resistance index were higher in the cariporide group (p < 0.05), respectively. More lung water accumulation was found in the cariporide group (p < 0.05). Mean Cpl decreased; the Qs/ Qt and glycerol in lung tissue increased without significant intergroup difference. In this model, the inhibitor of the Na+/H+ antiporter showed no protective effect on lung injury after CPB and might even have harmful effects on pulmonary vascular tone and function.
Wolfgang Eichler; Matthias J F Bechtel; Stephan Klaus; Matthias Heringlake; Mario Hernandez; Kai Toerber; Karl-Friedrich Klotz; Claus Bartels
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Publication Detail:
Type:  Evaluation Studies; Journal Article    
Journal Detail:
Title:  Perfusion     Volume:  19     ISSN:  0267-6591     ISO Abbreviation:  Perfusion     Publication Date:  2004 Jan 
Date Detail:
Created Date:  2004-04-09     Completed Date:  2004-10-05     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  8700166     Medline TA:  Perfusion     Country:  England    
Other Details:
Languages:  eng     Pagination:  33-40     Citation Subset:  IM    
Department of Anaesthesiology, University of Luebeck, Germany.
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MeSH Terms
Cardiopulmonary Bypass / adverse effects*
Extravascular Lung Water / drug effects,  metabolism
Guanidines / blood,  pharmacology*
Hemodynamics / drug effects
Pulmonary Circulation / drug effects
Pulmonary Gas Exchange / drug effects
Random Allocation
Respiration Disorders / etiology*,  physiopathology*
Sodium-Hydrogen Antiporter / antagonists & inhibitors*
Sulfones / blood,  pharmacology*
Reg. No./Substance:
0/Guanidines; 0/Sodium-Hydrogen Antiporter; 0/Sulfones; 0/cariporide

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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