Document Detail

Na+-Li+ countertransport and electrolyte composition in erythrocytes of patients with essential hypertension before and after antihypertensive treatment.
MedLine Citation:
PMID:  3807255     Owner:  NLM     Status:  MEDLINE    
The effect of antihypertensive treatment with 6-12 mg of the loop diuretic piretanide over 12 weeks on Na+-Li+ countertransport, and on extra- and intracellular electrolyte composition was studied in 10 previously untreated patients with essential hypertension. These data were compared with 10 sex- and age-matched controls. Blood pressure fell from 180 +/- 18.3/110.5 +/- 9.8 to 154.7 +/- 9.7/92.5 +/- 10.9 mmHg during treatment. Na+-Li+ countertransport was significantly higher in hypertensives (0.36 +/- 0.13 mmol X l-1 rbc X h-1) compared with controls (0.25 +/- 0.05; P less than 0.05). Na+-Li+ countertransport and intracellular electrolyte composition remained unchanged whereas the extracellular potassium concentration fell from 4.28 +/- 0.51 to 3.98 +/- 0.36 mmol/l (P less than 0.05). No increase in the intracellular Na+ content as compared with normotensive controls was found. It is concluded that the intracellular Na+ concentration is not a marker for essential hypertension. The Na+-Li+ countertransport does not seem to be directly related to elevated blood pressure but seems to be a general marker for diseases associated with an increased risk for the development of hypertension.
D Beuckelmann; E Erdmann
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Klinische Wochenschrift     Volume:  64     ISSN:  0023-2173     ISO Abbreviation:  Klin. Wochenschr.     Publication Date:  1986 Oct 
Date Detail:
Created Date:  1987-03-18     Completed Date:  1987-03-18     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  2985205R     Medline TA:  Klin Wochenschr     Country:  GERMANY, WEST    
Other Details:
Languages:  eng     Pagination:  1101-5     Citation Subset:  IM    
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MeSH Terms
Diuretics / therapeutic use*
Erythrocytes / metabolism*
Hypertension / blood*,  drug therapy
Lithium / blood*
Middle Aged
Sodium / blood*
Sulfonamides / therapeutic use*
Reg. No./Substance:
0/Diuretics; 0/Sulfonamides; 55837-27-9/piretanide; 7439-93-2/Lithium; 7440-23-5/Sodium

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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