| Na+, K(+)-ATPase and heart excitability. | |
| | |
MedLine Citation:
|
PMID: 8540400 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
The Na+, K(+)-activated adenosine triphosphatase (ATPase) is present in the membrane of eukaryotic cells and represent a major pathway for Na+ and K+ transport across the plasma membrane. Cardiac glycosides, such as digoxin or ouabain, inhibit this enzyme activity by binding to a specific receptor on the membrane. Studies conducted in this and other laboratories have proven the existence of digitalis-like compounds in animal and human tissues which may serve as regulators, in vivo, of the Na+, K(+)-pump activity. The levels of digitalis-like compounds in the plasma are increased in hypertension and other illnesses. A possible link at the cellular and molecular level between these compounds and etiology of arrhythmias, an important cause of morbidity and mortality in patients with various diseases of the heart, can be postulated: Na+, K(+)-ATPase activity contributes directly and indirectly to the electrical membrane potential of cardiac cells. The inhibition of this pump by the endogenous digitalis-like compounds, in discrete areas of the heart, can induce changes of the membrane potential of these cells. These changes may cause an increase in excitability of the particular cells and contribute to the generation of arrhythmias. |
| | |
Authors:
|
D Lichtstein |
Publication Detail:
|
Type: Journal Article; Review |
Journal Detail:
|
Title: Advances in experimental medicine and biology Volume: 382 ISSN: 0065-2598 ISO Abbreviation: Adv. Exp. Med. Biol. Publication Date: 1995 |
Date Detail:
|
Created Date: 1996-02-02 Completed Date: 1996-02-02 Revised Date: 2007-11-15 |
Medline Journal Info:
|
Nlm Unique ID: 0121103 Medline TA: Adv Exp Med Biol Country: UNITED STATES |
Other Details:
|
Languages: eng Pagination: 23-30 Citation Subset: IM |
Affiliation:
|
Department of Physiology, Hebrew University-Hadassah Medical School, Jerusalem, Israel. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Animals Heart / physiology* Humans Myocardial Contraction / physiology* Sodium-Potassium-Exchanging ATPase / physiology* |
| Chemical | |
Reg. No./Substance:
|
EC 3.6.3.9/Sodium-Potassium-Exchanging ATPase |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: The effect of cytotoxic lymphocytes on contraction, action potential and calcium handling in culture...
Next Document: Ventricular remodeling in heart failure: the role of myocardial collagen.