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Na, Cl, and water transport by rat colon.
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MedLine Citation:
PMID:  13813355     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Segments of the colon of anesthetized rats have been perfused in vivo with isotonic NaCl solutions and isotonic mixtures of NaCl and mannitol. Unidirectional and net fluxes of Na and Cl and the net fluxes of water and mannitol have been measured. Net water transport was found to depend directly on the rate of net Na transport. There was no water absorption from these isotonic solutions in the absence of net solute transport, indicating that water transport in the colon is entirely a passive process. At all NaCl concentrations studied, the lumen was found to be electrically negative to the surface of the colon by 5 to 15 mv. Na fluxes both into and out of the lumen were linear functions of NaCl concentration in the lumen. Net Na absorption from lumen to plasma has been observed to take place against an electrochemical potential gradient indicating that Na is actively transported. This active Na transport has been interpreted in terms of a carrier model system. Cl transport has been found to be due almost entirely to passive diffusion.
Authors:
P F CURRAN; G F SCHWARTZ
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  The Journal of general physiology     Volume:  43     ISSN:  0022-1295     ISO Abbreviation:  J. Gen. Physiol.     Publication Date:  1960 Jan 
Date Detail:
Created Date:  1960-12-01     Completed Date:  1998-11-01     Revised Date:  2010-06-22    
Medline Journal Info:
Nlm Unique ID:  2985110R     Medline TA:  J Gen Physiol     Country:  Not Available    
Other Details:
Languages:  eng     Pagination:  555-71     Citation Subset:  OM    
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MeSH Terms
Descriptor/Qualifier:
Chlorides / metabolism*
Colon / physiology*
Sodium / metabolism*
Water / metabolism*
Chemical
Reg. No./Substance:
0/Chlorides; 7440-23-5/Sodium; 7732-18-5/Water
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Full Text
Journal Information
Journal ID (nlm-ta): J Gen Physiol
ISSN: 0022-1295
ISSN: 1540-7748
Publisher: The Rockefeller University Press
Article Information
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Copyright © Copyright, 1960, by The Rockefeller Institute
Received Day: 6 Month: 5 Year: 1959
Print publication date: Day: 1 Month: 1 Year: 1960
Volume: 43 Issue: 3
First Page: 555 Last Page: 571
ID: 2195008
PubMed Id: 13813355

Na, Cl, and Water Transport by Rat Colon
Peter F. Curran
Gordon F. Schwartz
From the Biophysical Laboratory, Harvard Medical School, Boston. Dr. Curran is a Public Health Service Research Fellow of the National Heart Institute.
From the Biophysical Laboratory, Harvard Medical School, Boston.
His present address is: Institute of Biological Chemistry, University of Copenhagen, Copenhagen.


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