Document Detail


NTP-CERHR Monograph on the Potential Human Reproductive and Developmental Effects of Acrylamide.
MedLine Citation:
PMID:  15995732     Owner:  NLM     Status:  In-Data-Review    
Abstract/OtherAbstract:
The National Toxicology Program (NTP) Center for the Evaluation of Risks to Human Reproduction (CERHR) conducted an evaluation of the potential for acrylamide to cause adverse effects on reproduction and development in humans. Acrylamide was selected for evaluation because of recent public concern for human exposures through its presence in some prepared foods, especially starchy foods cooked at high temperatures, such as French fries and potato chips. Acrylamide is used in the production of polyacrylamide, which is used in water treatment, pulp and paper production, and mineral processing. Polyacrylamide is also used in the synthesis of dyes, adhesives, contact lenses, soil conditioners, cosmetics and skin creams, food packaging materials, and permanent press fabrics. The results of this evaluation on acrylamide are published in an NTP-CERHR monograph which includes: 1) the NTP Brief, 2) the Expert Panel Report on the Reproductive and Developmental Toxicity of Acrylamide, and 3) public comments received on the Expert Panel Report. As stated in the NTP Brief, the NTP reached the following conclusions regarding the possible effects of exposure to acrylamide on human development and reproduction. First, there is negligible concern for adverse developmental and reproductive effects from acrylamide exposure to the general population. There is no direct evidence that exposure of the general population to acrylamide adversely affects reproduction or development. Acrylamide exposure in the general US population was estimated by the panel to be 0.43 mug/kg body weight/day, levels far below those that induce reproductive and developmental toxicity in experimental animals. Second, there is minimal concern for acrylamide-induced heritable effects in the general population. This conclusion is based on evidence that exposure of male laboratory rodents to high doses of acrylamide causes genetic damage in sperm. Because of the magnitude of the effects observed at the doses tested, there was a likelihood that similar effects could occur at lower doses. Finally, there is some concern for adverse reproductive and developmental effects from occupational acrylamide exposures. Studies in laboratory animals have shown exposure levels which induce neurotoxicity sometimes induce reproductive or developmental toxicity. Because neurotoxicity has been reported in people as a result of high acrylamide exposures in some occupational settings, there is a possibility of adverse reproductive or developmental effects. NTP-CERHR monographs are transmitted to federal and state agencies, interested parties, and the public and are available in electronic PDF format on the CERHR web site (http://cerhr.niehs.nih.gov) and in printed text or CD-ROM from the CERHR (National Institute of Environmental Health Sciences, P.O. Box 12233, MD EC-32, Research Triangle Park, NC; fax: 919-316-4511).
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  NTP CERHR MON     Volume:  -     ISSN:  1556-2271     ISO Abbreviation:  NTP CERHR MON     Publication Date:  2005 Feb 
Date Detail:
Created Date:  2005-07-04     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101229556     Medline TA:  NTP CERHR MON     Country:  United States    
Other Details:
Languages:  eng     Pagination:  i-III76     Citation Subset:  IM    
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