Document Detail


NT-proBNP and echocardiographic parameters in patients with acute heart failure.
MedLine Citation:
PMID:  17654836     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
AIM: The aim of this study was to analyse the relation between clinical, haemodynamic and X-ray parameters and plasma NT-proBNP level in pts with symptoms of left ventricular dysfunction. METHODS: The plasma NT-proBNP levels, chest x-ray, transthoracic 2-d and Doppler echocardiography were performed at the time of admission in a group of 96 consecutive patients (mean age 68 +/- 11 years) with symptoms of acute heart failure. NT-proBNP levels were assessed with the use of commercial tests (Roche Diagnostics). RESULTS: All patients have significant increase in NT-proBNP (8000 +/- 9000 pg/mL vs. controls 90 +/- 80 pg/mL, p < 0.001). The group of all patients has shown a significant increase in cardiothoracic ratio (CTR, 0.6 +/- 0.1, vs. 0.4 +/- 0.1, p < 0.001), left atrium diameter (LAD, 4.4 +/- 0.8 cm, vs.3.5 +/- 0.4 cm, p < 0.01). Left ventricular ejection fraction (LVEF) was decreased (37 +/- 15%, vs. 64 +/- 5%, p < 0.001). In patients with acute heart failure, NT-proBNP significantly correlated with end-systolic and end-diastolic left ventricle diameters, ejection fraction, vena cava inferior diameter and plasma creatinine levels. CONCLUSION: Increased plasma NT-proBNP level is influenced by the clinical severity of acute heart failure and correlates with LVEF and IVCD. NT-proBNP can serve as a marker for the clinical severity of the disease.
Authors:
Radek Pudil; Milos Tichý; Rudolf Praus; Václav Bláha; Jan Vojácek
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Acta medica (Hradec Králové) / Universitas Carolina, Facultas Medica Hradec Králové     Volume:  50     ISSN:  1211-4286     ISO Abbreviation:  Acta Medica (Hradec Kralove)     Publication Date:  2007  
Date Detail:
Created Date:  2007-07-27     Completed Date:  2007-08-28     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  9705947     Medline TA:  Acta Medica (Hradec Kralove)     Country:  Czech Republic    
Other Details:
Languages:  eng     Pagination:  51-6     Citation Subset:  IM    
Affiliation:
Charles University in Prague, Faculty of Medicine in Hradec Králové, 1st Department of Medicine, Division of Cardiology, Czech Republic. pudilradek@yahoo.com
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MeSH Terms
Descriptor/Qualifier:
Acute Disease
Adult
Aged
Aged, 80 and over
Echocardiography*
Female
Heart Failure / blood*,  complications,  ultrasonography*
Humans
Male
Middle Aged
Natriuretic Peptide, Brain / blood*
Peptide Fragments / blood*
Ventricular Dysfunction, Left / complications,  ultrasonography
Chemical
Reg. No./Substance:
0/Peptide Fragments; 0/pro-brain natriuretic peptide (1-76); 114471-18-0/Natriuretic Peptide, Brain

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