Document Detail

NT-proBNP does not rise on acute ascent to high altitude.
MedLine Citation:
PMID:  19115915     Owner:  NLM     Status:  MEDLINE    
The response of brain natriuretic peptide (BNP) to acute ascent to altitude is of interest as a surrogate for ventricular function and because BNP is involved in the normal homeostasis of the pulmonary vasculature. The structurally related hormone atrial natriuretic pressure (ANP) has been demonstrated to be elevated at altitude and implicated in natriuresis. We measured plasma concentrations of ANP and NT-proBNP (a more stable BNP precursor) in 10 healthy non-HAPE-susceptible lowlanders during acute exposure to 5200 m on the Apex 2 expedition to Bolivia. Systolic pulmonary artery pressure (PASP) was measured using tricuspid regurgitant jet estimation by echocardiography. Despite a significant rise in the PASP, NT-proBNP did not rise. A small decrease in NT-pro BNP occurred after 7 days at high altitude. There was no significant change in ANP levels. The lack of any increase in NT-proBNP in healthy resting subjects supports the view that ventricular function is well preserved and suggests that BNP is not playing a significant role in altered pulmonary artery pressure.
Mark R Toshner; A A Roger Thompson; John B Irving; J Kenneth Baillie; J J Morton; Andrew J Peacock
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  High altitude medicine & biology     Volume:  9     ISSN:  1527-0297     ISO Abbreviation:  High Alt. Med. Biol.     Publication Date:  2008  
Date Detail:
Created Date:  2008-12-31     Completed Date:  2009-04-23     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  100901183     Medline TA:  High Alt Med Biol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  307-10     Citation Subset:  IM; S    
Pulmonary Vascular Diseases Unit, Papworth Hospital, Cambridgeshire, England, UK.
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MeSH Terms
Acute Disease
Altitude Sickness / blood,  diagnosis
Biological Markers / blood
Blood Pressure / physiology*
Environmental Monitoring*
Natriuretic Peptide, Brain / blood*
Peptide Fragments / blood*
Pulmonary Wedge Pressure / physiology
Reference Values
Statistics, Nonparametric
Ventricular Function / physiology
Young Adult
Reg. No./Substance:
0/Biological Markers; 0/Peptide Fragments; 0/pro-brain natriuretic peptide (1-76); 114471-18-0/Natriuretic Peptide, Brain

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