Document Detail

NT-proBNP correlates with right heart haemodynamic parameters and volumes in patients with atrial septal defects.
MedLine Citation:
PMID:  17347036     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: To investigate the role of N-terminal pro-BNP (NT-proBNP) for the estimation of right heart failure and pulmonary pressure in patients with atrial septal defects (ASD) before and after percutaneous defect closure.
METHODS: We performed correlation analysis for NT-proBNP and right ventricular systolic pressure (RVSP) as well as right ventricular enddiastolic and endsystolic volume (RVEDV, RVESV) determined by cardiac magnetic resonance imaging (MRI) before and up to one year following ASD closure. Additionally NT-proBNP concentrations were correlated with right atrial (RA) and RV enddiastolic pressure (RVEDP), ASD size and interatrial left-to-right shunt.
RESULTS: Baseline RVSP was 33+/-8 mmHg, which decreased significantly during follow-up. Initially, NT-proBNP levels were 240+/-93 pg/ml. After closure, a reduction to 116+/-62 pg/ml was obvious (p<0.01). Baseline MRI showed enlarged RV volumes in all individuals. At six and twelve months follow-up a significant reduction of RVEDV and RVESV was apparent. A positive correlation was noted between RV volumes and NT-proBNP (r=0.65, p<0.05). Furthermore RA pressure, RVEDP, RVSP and left-to-right shunt significantly correlated to peptide levels. No correlation was seen between ASD size and NT-proBNP.
CONCLUSION: NT-proBNP correlates to right ventricular dilatation, pulmonary pressure and left-to-right shunt in volume load of the right heart caused by an underlying ASD.
S P Schoen; T Zimmermann; T Kittner; M U Braun; J Fuhrmann; A Schmeisser; R H Strasser
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Publication Detail:
Type:  Journal Article     Date:  2007-03-07
Journal Detail:
Title:  European journal of heart failure     Volume:  9     ISSN:  1388-9842     ISO Abbreviation:  Eur. J. Heart Fail.     Publication Date:    2007 Jun-Jul
Date Detail:
Created Date:  2007-05-14     Completed Date:  2007-08-17     Revised Date:  2011-06-08    
Medline Journal Info:
Nlm Unique ID:  100887595     Medline TA:  Eur J Heart Fail     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  660-6     Citation Subset:  IM    
Department of Cardiology, University of Dresden, Heart Center, Dresden, Germany. <>
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MeSH Terms
Atrial Function, Right / physiology
Blood Pressure / physiology*
Cardiac Volume / physiology*
Diastole / physiology
Follow-Up Studies
Heart Catheterization
Heart Failure / diagnosis,  physiopathology*,  surgery
Heart Septal Defects, Atrial / diagnosis,  physiopathology*,  surgery
Magnetic Resonance Imaging
Middle Aged
Natriuretic Peptide, Brain / blood*
Peptide Fragments / blood*
Postoperative Complications / diagnosis,  physiopathology
Reference Values
Statistics as Topic
Systole / physiology
Ventricular Dysfunction, Right / diagnosis,  physiopathology*,  surgery
Ventricular Function, Right / physiology
Reg. No./Substance:
0/Peptide Fragments; 0/pro-brain natriuretic peptide (1-76); 114471-18-0/Natriuretic Peptide, Brain

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