Document Detail

NT-proBNP concentrations in mountain marathoners.
MedLine Citation:
PMID:  20393354     Owner:  NLM     Status:  MEDLINE    
The 76 amino acid N-terminal proB-type natriuretic peptide (NT-proBNP) is proposed for evaluating and monitoring heart pathologies characterized by myocardial wall stress. Strenuous exercise might generate transitory ischemia, myocardial stress, and diastolic left ventricular dysfunction, possibly inducing an increase of some biochemical parameter concentrations. An alert has been claimed owing to biochemical and instrumental signs of heart dysfunction in recreational athletes during marathon races. We studied the behaviour of NT-proBNP in 15 mountain marathoners before and after a race. The concentrations of the parameter were lower than that observed in controls at rest and were similar to that observed in professional soccer and rugby players. The concentrations significantly increased after the race. NT-proBNP is low at rest in professional athletes, and the increase after physical exercise is physiological. The marathoners, even when performing races in a high-altitude environment, show NT-proBNP concentrations similar to those of athletes from other sports disciplines, characterized by low levels of effort and by a mix of aerobic and anaerobic metabolism. The increase of NT-proBNP is linked to strenuous physical exercise and to heavy heart effort, testified also by an increase of troponin I. However, the role of the NT-proBNP could be important to screen recreational and professional marathoners to avoid possible heart problems and sudden cardiac death in subjects with occult heart disease. The results of the present study are relevant to the design and evaluation of training programs for improving strength and function of professional marathoners.
Giuseppe Banfi; Giuseppe Lippi; Daniele Susta; Alessandra Barassi; Gianvico Melzi D'Eril; Giada Dogliotti; Massimiliano M Corsi
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of strength and conditioning research / National Strength & Conditioning Association     Volume:  24     ISSN:  1533-4287     ISO Abbreviation:  J Strength Cond Res     Publication Date:  2010 May 
Date Detail:
Created Date:  2010-05-04     Completed Date:  2010-08-04     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9415084     Medline TA:  J Strength Cond Res     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1369-72     Citation Subset:  IM    
Institute R. Galeazzi, IRCCS, I- 20161 Milan, Italy.
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MeSH Terms
Bicycling / physiology*
Biological Markers
Case-Control Studies
Death, Sudden, Cardiac / prevention & control
Heart Diseases / blood,  prevention & control*
Natriuretic Peptide, Brain / blood*
Peptide Fragments / blood*
Physical Exertion / physiology*
Reg. No./Substance:
0/Biological Markers; 0/Peptide Fragments; 0/pro-brain natriuretic peptide (1-76); 114471-18-0/Natriuretic Peptide, Brain

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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