Document Detail

NT-ProBNP in acute heart failure: correlation with invasively measured hemodynamic parameters during recompensation.
MedLine Citation:
PMID:  15948099     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: N-terminal brain natriuretic peptide (NT-proBNP) level is elevated in patients with acute and chronic heart failure. This study addresses whether NT-proBNP correlates with invasively measured hemodynamic parameters and whether a decrease of NT-proBNP over time correlates with invasively monitored hemodynamic improvement. METHODS AND RESULTS: Twenty consecutive patients with acute exacerbation of chronic heart failure (New York Heart Association class III-IV) were included in this prospective study. NT-proBNP and hemodynamic measurements by balloon-tipped pulmonary artery catheter were performed simultaneously. Recompensation strategies included vasodilators, diuretics, and inotropes. The patients were divided in 2 subgroups. Group A, by definition, had a hemodynamic improvement over 24 hours with an increase of cardiac index of >30% and a decrease of pulmonary capillary wedge pressure of >30%. Group B did not show a hemodynamic improvement. Group A had a decline of NT-proBNP levels to 42% of the baseline value over 32 hours. In group B, the NT-pro BNP levels did not change significantly over 32 hours. CONCLUSION: The decrease of NT-proBNP correlates with hemodynamic improvement in patients with decompensated heart failure. The relative changes of NT-proBNP seem to be a reliable diagnostic tool in monitoring these patients. There results have been confirmed in a larger patient group.
Fabian Knebel; Ingolf Schimke; Kathleen Pliet; Sebastian Schattke; Salim Martin; Adrian C Borges; Gert Baumann
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of cardiac failure     Volume:  11     ISSN:  1071-9164     ISO Abbreviation:  J. Card. Fail.     Publication Date:  2005 Jun 
Date Detail:
Created Date:  2005-06-10     Completed Date:  2006-03-09     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  9442138     Medline TA:  J Card Fail     Country:  United States    
Other Details:
Languages:  eng     Pagination:  S38-41     Citation Subset:  IM    
Medical Clinic for Cardiology, Angiology, and Pneumology, Charité Campus Mitte--University Medicine, Berlin, Germany.
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MeSH Terms
Biological Markers / blood
Catheterization, Swan-Ganz
Heart Failure / blood,  diagnosis*,  physiopathology
Intensive Care Units
Middle Aged
Natriuretic Peptide, Brain / blood*
Peptide Fragments / blood*
Prospective Studies
Pulmonary Wedge Pressure
Retrospective Studies
Stroke Volume
Time Factors
Vascular Resistance
Reg. No./Substance:
0/Biological Markers; 0/Peptide Fragments; 0/pro-brain natriuretic peptide (1-76); 114471-18-0/Natriuretic Peptide, Brain

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