| NT-ProBNP in acute heart failure: correlation with invasively measured hemodynamic parameters during recompensation. | |
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MedLine Citation:
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PMID: 15948099 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: N-terminal brain natriuretic peptide (NT-proBNP) level is elevated in patients with acute and chronic heart failure. This study addresses whether NT-proBNP correlates with invasively measured hemodynamic parameters and whether a decrease of NT-proBNP over time correlates with invasively monitored hemodynamic improvement. METHODS AND RESULTS: Twenty consecutive patients with acute exacerbation of chronic heart failure (New York Heart Association class III-IV) were included in this prospective study. NT-proBNP and hemodynamic measurements by balloon-tipped pulmonary artery catheter were performed simultaneously. Recompensation strategies included vasodilators, diuretics, and inotropes. The patients were divided in 2 subgroups. Group A, by definition, had a hemodynamic improvement over 24 hours with an increase of cardiac index of >30% and a decrease of pulmonary capillary wedge pressure of >30%. Group B did not show a hemodynamic improvement. Group A had a decline of NT-proBNP levels to 42% of the baseline value over 32 hours. In group B, the NT-pro BNP levels did not change significantly over 32 hours. CONCLUSION: The decrease of NT-proBNP correlates with hemodynamic improvement in patients with decompensated heart failure. The relative changes of NT-proBNP seem to be a reliable diagnostic tool in monitoring these patients. There results have been confirmed in a larger patient group. |
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Authors:
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Fabian Knebel; Ingolf Schimke; Kathleen Pliet; Sebastian Schattke; Salim Martin; Adrian C Borges; Gert Baumann |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Journal of cardiac failure Volume: 11 ISSN: 1071-9164 ISO Abbreviation: J. Card. Fail. Publication Date: 2005 Jun |
Date Detail:
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Created Date: 2005-06-10 Completed Date: 2006-03-09 Revised Date: 2007-11-15 |
Medline Journal Info:
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Nlm Unique ID: 9442138 Medline TA: J Card Fail Country: United States |
Other Details:
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Languages: eng Pagination: S38-41 Citation Subset: IM |
Affiliation:
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Medical Clinic for Cardiology, Angiology, and Pneumology, Charité Campus Mitte--University Medicine, Berlin, Germany. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Biological Markers
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blood Catheterization, Swan-Ganz Female Heart Failure / blood, diagnosis*, physiopathology Humans Intensive Care Units Male Middle Aged Natriuretic Peptide, Brain / blood* Peptide Fragments / blood* Prospective Studies Pulmonary Wedge Pressure Retrospective Studies Stroke Volume Time Factors Vascular Resistance |
| Chemical | |
Reg. No./Substance:
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0/Biological Markers; 0/Peptide Fragments; 0/pro-brain natriuretic peptide (1-76); 114471-18-0/Natriuretic Peptide, Brain |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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