Document Detail

NT-Pro-BNP levels and their response to exercise in patients with slow coronary flow.
MedLine Citation:
PMID:  23152289     Owner:  NLM     Status:  Publisher    
BACKGROUND: Natriuretic peptides are released by the heart in response to wall stress. OBJECTIVE: The NT-Pro-BNP concentrations in slow coronary flow (SCF) patients were assessed before and after the exercise test and compared with the values of healthy controls. METHODS: The study population was 34 patients with SCF [22 males (64.7%), aged 51.0±6.2 years], and 34 normal subjects with normal coronary arteries [21 males (61.8%), aged 53.2±6.6 years]. Coronary flow rates of all patients and control subjects were documented as Thrombolysis in Myocardial Infarction (TIMI) frame count. Blood samples were drawn at rest and after the exercise testing. RESULTS: The baseline NT-Pro-BNP concentrations of the SCF patients were higher than those of the control subjects (NT-Pro-BNP: 49.7±14.2 pg/mL vs. 25.3±4.6 pg/mL p<0.0001, respectively), and this difference increased after exercise test between the groups (NT-Pro-BNP: 69.5±18.6 pg/mL vs. 30.9±6.4 pg/mL p<0.0001). In SCF group after exercise, NT-Pro-BNP concentration in 15 patients with angina was higher than those without angina (76.8 ± 17.8 pg/mL vs. 63.8±17.5 pg/mL p=0.041). NT-Pro-BNP concentration in 11 patients with ST depression was also higher than those without ST depression (82.4 ± 17.3 pg/mL vs. 63.3 ± 16.1 pg/mL p=0.004). Median post-exercise increases in NT-Pro-BNP (Δ NT-Pro-BNP) were higher in the SCF group than in the control group (Δ NT-Pro-BNP: 19.8±7.7 pg/mL vs. 5.7±4.5 pg/mL p<0.0001). CONCLUSION: The results of this study suggest that there may be an important pathophysiologic link between the severity of SCF (microvascular or epicardial coronary artery dysfunction) and the level of circulating NT-Pro-BNP in SCF patients.
Mustafa Yurtdaş; Ismail Türkay Ozcan; Ahmet Camsar; Dilek Ciçek; Lülüfer Tamer; Veli Gökhan Cin; Oben Döven; Ali Sabri Seyis; Mehmet Necdet Akkuş
Related Documents :
9366319 - Urodynamic effects of intravesical resiniferatoxin in humans: preliminary results in st...
23045469 - Impact of exercise training on preeclampsia: potential preventive mechanisms.
18609189 - Short-term moderate exercise programs reduce oxidative dna damage as determined by high...
16286099 - Shock wave lithotripsy success determined by skin-to-stone distance on computed tomogra...
17376759 - Spinal glutamatergic nmda-dependent cyclic pelvic nerve-to-external urethra sphincter r...
24888429 - Physical ischemia induced by isometric exercise facilitated collateral development in t...
10228119 - Physiologic response of ventilator-dependent patients with chronic obstructive pulmonar...
2026989 - Acupuncture in angina pectoris: does acupuncture have a specific effect?
23029959 - Effect of short duration aerobic exercise training on reflection index, stiffness index...
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-11-16
Journal Detail:
Title:  Arquivos brasileiros de cardiologia     Volume:  -     ISSN:  1678-4170     ISO Abbreviation:  Arq. Bras. Cardiol.     Publication Date:  2012 Nov 
Date Detail:
Created Date:  2012-11-15     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0421031     Medline TA:  Arq Bras Cardiol     Country:  -    
Other Details:
Languages:  ENG; POR     Pagination:  -     Citation Subset:  -    
Department of Cardiology, Medisina Hospital, Van, Turquia.
Vernacular Title:
Níveis NT-Pro-BNP e resposta ao exercício em pacientes com fluxo lento coronariano.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Assessment of stent strut endothelialization in iliac arteries of rabbits.
Next Document:  Transthoracic impedance compared to magnetic resonance imaging in the assessment of cardiac output.