Document Detail

NSSR1 is regulated by testosterone in the mouse uterus and extensively expressed in endometrial carcinoma.
MedLine Citation:
PMID:  21072693     Owner:  NLM     Status:  MEDLINE    
Neural salient serine/arginine-rich protein 1 (NSSR1) has been found to play important roles in inhibiting alternative splicing during heat shock and mitosis and is predominantly expressed in neural tissues such as cerebral neurons, cerebellar Purkinje cells and bipolar cells of the retina. Recently, NSSR1 has also been shown to be highly expressed in the testes, suggesting its potential roles in reproductive system. In this report, the expression of NSSR1 in the columnar epithelium of the endometrium and gland epithelium during the development of the mouse uterus, the regulation of NSSR1 level by testosterone in the adult mouse uterus, and expression level of NSSR1 in both human endometrial carcinomas and ovarian cancers were analyzed by quantitative real-time polymerase chain reaction (qRT-PCR), Western blot, and immunohistochemistry. We demonstrated that the expression of NSSR1 was developmentally regulated in the columnar epithelium of the endometrium and gland epithelium in the mouse uterus. Additionally, the NSSR1 level in the mouse uterus was maintained and regulated by testosterone. Interestingly, an enhanced level of NSSR1 was observed in both human endometrial carcinomas and ovarian cancers. Our results suggest that expression and distribution of NSSR1 is developmentally and hormonally regulated and up-regulated in endometrial carcinomas as well as ovarian cancers, indicating its potential involvement in uterine development and tumorgenesis.
Zheng-Yu Peng; Ping-Jie Xiao; Yao Qi; Wei Zhang; Xian-Hua Chen; Ping Xu
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2010-11-12
Journal Detail:
Title:  Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine     Volume:  32     ISSN:  1423-0380     ISO Abbreviation:  Tumour Biol.     Publication Date:  2011 Apr 
Date Detail:
Created Date:  2011-02-21     Completed Date:  2011-04-11     Revised Date:  2012-03-02    
Medline Journal Info:
Nlm Unique ID:  8409922     Medline TA:  Tumour Biol     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  359-66     Citation Subset:  IM    
State Key Laboratory of Medical Neurobiology, Fudan University, Shanghai 200032, China.
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MeSH Terms
Case-Control Studies
Cell Cycle Proteins / drug effects,  metabolism*
Endometrial Neoplasms / metabolism*,  pathology
Gene Expression Regulation, Neoplastic
Mice, Inbred Strains
Models, Animal
Neoplasm Proteins / drug effects,  metabolism*
Ovarian Neoplasms / metabolism,  pathology
RNA-Binding Proteins / drug effects,  metabolism*
Repressor Proteins / drug effects,  metabolism*
Testosterone / pharmacology*
Tumor Markers, Biological / metabolism*
Uterus / metabolism*
Reg. No./Substance:
0/Cell Cycle Proteins; 0/Fusip1 protein, mouse; 0/Neoplasm Proteins; 0/RNA-Binding Proteins; 0/Repressor Proteins; 0/SRSF10 protein, human; 0/Tumor Markers, Biological; 58-22-0/Testosterone

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