| The NSD3L histone methyltransferase regulates cell cycle and cell invasion in breast cancer cells. | |
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MedLine Citation:
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PMID: 20599755 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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NSD3/WHSC1L1 histone methyltransferase gene aberrations are observed in leukemia and in breast and lung carcinomas, suggesting that NSD3 is implicated in carcinogenesis. In this study we examined in human breast cancer cells the NSD3L isoform which contains the catalytic histone methyltransferase SET-domain. siRNA directed depletion of NSD3L followed by genome-wide microarray analysis identified NSD3L regulated genes which could be functionally linked to cellular signaling pathways such as cell growth, cell cycle, cell motility, transcription, and apoptosis. Notably up-regulated genes are the cell cycle regulators E2F2 and Arl2. In accordance with a function of NSD3L in cell cycle regulation NSD3L depletion resulted in an increase in the number of cells in the S and G2/M cell cycle phases. Moreover, NSD3L depletion increased the invasiveness of MDA-MB-231 breast cancer cells indicating that NSD3L normally restrain cellular metastatic potential. Together the presented data indicates that NSD3L is a candidate tumor suppressor. |
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Authors:
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Zhangle Zhou; Rune Thomsen; Søren Kahns; Anders Lade Nielsen |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2010-07-01 |
Journal Detail:
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Title: Biochemical and biophysical research communications Volume: 398 ISSN: 1090-2104 ISO Abbreviation: Biochem. Biophys. Res. Commun. Publication Date: 2010 Jul |
Date Detail:
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Created Date: 2010-08-03 Completed Date: 2010-09-08 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0372516 Medline TA: Biochem Biophys Res Commun Country: United States |
Other Details:
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Languages: eng Pagination: 565-70 Citation Subset: IM |
Copyright Information:
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Copyright 2010 Elsevier Inc. All rights reserved. |
Affiliation:
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Department of Human Genetics, Aarhus University, Denmark. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Breast Neoplasms
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enzymology,
genetics,
pathology* Cell Cycle / genetics* Cell Line, Tumor Female Gene Expression Regulation, Neoplastic* Genome-Wide Association Study Histone-Lysine N-Methyltransferase / genetics, metabolism* Humans Neoplasm Invasiveness Nuclear Proteins / genetics, metabolism* Protein Isoforms / genetics, metabolism RNA, Small Interfering / genetics Tumor Suppressor Proteins / genetics, metabolism* |
| Chemical | |
Reg. No./Substance:
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0/Nuclear Proteins; 0/Protein Isoforms; 0/RNA, Small Interfering; 0/Tumor Suppressor Proteins; EC 2.1.1.43/Histone-Lysine N-Methyltransferase; EC 2.1.1.43/WHSC1L1 protein, human |
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