Document Detail

NSAIDs: maternal and fetal considerations.
MedLine Citation:
PMID:  1285865     Owner:  NLM     Status:  MEDLINE    
Nonsteroidal anti-inflammatory drugs (NSAIDs) gained popularity in the late 1970s. Inhibition of prostaglandin synthesis with indomethacin has been reported to be effective for prevention of labor and for treatment for symptomatic polyhydramnios. Concern about its possible constrictive effect on the fetal ductus arteriosus has limited its use in pregnancy. Maternal indomethacin therapy has also been associated with reduction in urine production in the fetus and with oligohydramnios. Obstetricians have discouraged pregnant women from taking analgesic doses of aspirin, mainly because of the availability of paracetamol (acetaminophen), which causes less gastric irritation, but also because of fear of maternal and fetal hemorrhage and of possible premature closure of the ductus. These fears largely derive from studies on patients taking large doses and from extrapolation from other NSAIDs. The likelihood that treatment with 60-75 mg/day of aspirin markedly reduces the incidence of preeclampsia and fetal intrauterine growth retardation makes it important to reexamine its use. This review describes the pharmacology and pharmacokinetics of aspirin with particular reference to pregnancy and considers teratogenesis, prolongation of pregnancy and labor, maternal bleeding, fetal and neonatal bleeding, possible effects on the ductus arteriosus and pulmonary circulation, and possible nonspecific effects on intelligence and breast feeding and acute toxicity in the neonate.
A Schoenfeld; Y Bar; P Merlob; Y Ovadia
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  American journal of reproductive immunology (New York, N.Y. : 1989)     Volume:  28     ISSN:  1046-7408     ISO Abbreviation:  Am. J. Reprod. Immunol.     Publication Date:    1992 Oct-Dec
Date Detail:
Created Date:  1993-03-18     Completed Date:  1993-03-18     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  8912860     Medline TA:  Am J Reprod Immunol     Country:  DENMARK    
Other Details:
Languages:  eng     Pagination:  141-7     Citation Subset:  IM    
Department of Obstetrics & Gynecology, Beilinson Medical Center, Petabh-Tiqva, Israel.
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MeSH Terms
Abnormalities, Drug-Induced / etiology
Acetaminophen / adverse effects,  pharmacokinetics
Anti-Inflammatory Agents, Non-Steroidal / adverse effects*,  therapeutic use
Aspirin / administration & dosage,  adverse effects,  pharmacokinetics
Drug Evaluation
Ductus Arteriosus / drug effects
Fetus / drug effects*
Ibuprofen / adverse effects,  pharmacokinetics
Infant, Newborn
Intelligence / drug effects
Pregnancy Complications / drug therapy*
Rheumatic Diseases / drug therapy
Sulindac / adverse effects,  pharmacokinetics
Tocolytic Agents / adverse effects,  therapeutic use
Reg. No./Substance:
0/Anti-Inflammatory Agents, Non-Steroidal; 0/Tocolytic Agents; 103-90-2/Acetaminophen; 15687-27-1/Ibuprofen; 38194-50-2/Sulindac; 50-78-2/Aspirin

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