| NSAIDs and acidic environment induce gastric mucosal cellular mitochondrial dysfunction. | |
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MedLine Citation:
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PMID: 22269294 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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Non-steroidal anti-inflammatory drugs (NSAIDs) often cause gastrointestinal complications such as gastric ulcers and erosions. Recent studies on the pathogenesis have revealed that NSAIDs induce lipid peroxidation in gastric epithelial cells by generating superoxide in mitochondria, independently with cyclooxygenase inhibition and the subsequent prostaglandin deficiency. More recently, gastric hydrochloric acid (HCl) has been regarded as an inciting factor of gastric mucosal injuries, and reportedly induced cellular lipid peroxidation in vitro. We hypothesized that gastric acid and NSAID treatment synergistically induce cellular injury in gastric epithelial cells. We treated gastric epithelial RGM1 cells with acidic solutions and NSAIDs, and examined cellular injury, lipid peroxidation, mitochondrial transmenbrane potential and mitochondrial superoxide. We pretreated RGM1 cells with the acidic solutions for 0.5 h and after that treated them with each NSAID for 15 h and found that the exposure to acid and NSAIDs indeed induced cellular injury. We hypothesized that gastric acid and NSAID treatment synergistically induce mitochondrial superoxide production, which induces gastric cellular injury. |
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Authors:
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Yumiko Nagano; Hirofumi Matsui; Masato Tamura; Osamu Shimokawa; Yukio Nakamura; Tsuyoshi Kaneko; Ichinosuke Hyodo |
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Publication Detail:
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Type: Journal Article Date: 2012-01-19 |
Journal Detail:
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Title: Digestion Volume: 85 ISSN: 1421-9867 ISO Abbreviation: Digestion Publication Date: 2012 |
Date Detail:
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Created Date: 2012-01-24 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0150472 Medline TA: Digestion Country: Switzerland |
Other Details:
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Languages: eng Pagination: 131-5 Citation Subset: IM |
Copyright Information:
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Copyright © 2012 S. Karger AG, Basel. |
Affiliation:
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The Graduate School of Comprehensive Human Sciences, University of Tsukuba, Tsukuba, Japan. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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