| NSA2, a novel nucleolus protein regulates cell proliferation and cell cycle. | |
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MedLine Citation:
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PMID: 19932687 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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NSA2 (Nop seven-associated 2) was previously identified in a high throughput screen of novel human genes associated with cell proliferation, and the NSA2 protein is evolutionarily conserved across different species. In this study, we revealed that NSA2 is broadly expressed in human tissues and cultured cell lines, and located in the nucleolus of the cell. Both of the putative nuclear localization signals (NLSs) of NSA2, also overlapped with nucleolar localization signals (NoLSs), are capable of directing nucleolar accumulation. Moreover, over-expression of the NSA2 protein promoted cell growth in different cell lines and regulated the G1/S transition in the cell cycle. SiRNA silencing of the NSA2 transcript attenuated the cell growth and dramatically blocked the cell cycle in G1/S transition. Our results demonstrated that NSA2 is a nucleolar protein involved in cell proliferation and cell cycle regulation. |
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Authors:
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Heyu Zhang; Xi Ma; Taiping Shi; Quansheng Song; Hongshan Zhao; Dalong Ma |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2009-11-22 |
Journal Detail:
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Title: Biochemical and biophysical research communications Volume: 391 ISSN: 1090-2104 ISO Abbreviation: Biochem. Biophys. Res. Commun. Publication Date: 2010 Jan |
Date Detail:
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Created Date: 2010-01-27 Completed Date: 2010-03-15 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0372516 Medline TA: Biochem Biophys Res Commun Country: United States |
Other Details:
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Languages: eng Pagination: 651-8 Citation Subset: IM |
Copyright Information:
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Copyright 2009 Elsevier Inc. All rights reserved. |
Affiliation:
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Department of Immunology, School of Basic Medical Sciences, Peking University, No 38 Xueyuan Road, Beijing 100191, PR China. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Amino Acid Sequence Cell Cycle* Cell Line Cell Line, Tumor Cell Nucleolus / metabolism* Cell Proliferation* Down-Regulation G1 Phase Hela Cells Humans Molecular Sequence Data Nuclear Localization Signals / genetics, metabolism Nuclear Proteins / classification, genetics, metabolism Phylogeny S Phase |
| Chemical | |
Reg. No./Substance:
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0/NSA2 protein, human; 0/Nuclear Localization Signals; 0/Nuclear Proteins |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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