Document Detail

NS1 proteins of avian influenza A viruses can act as antagonists of the human alpha/beta interferon response.
MedLine Citation:
PMID:  17182679     Owner:  NLM     Status:  MEDLINE    
Many viruses, including human influenza A virus, have developed strategies for counteracting the host type I interferon (IFN) response. We have explored whether avian influenza viruses were less capable of combating the type I IFN response in mammalian cells, as this might be a determinant of host range restriction. A panel of avian influenza viruses isolated between 1927 and 1997 was assembled. The selected viruses showed variation in their ability to activate the expression of a reporter gene under the control of the IFN-beta promoter and in the levels of IFN induced in mammalian cells. Surprisingly, the avian NS1 proteins expressed alone or in the genetic background of a human influenza virus controlled IFN-beta induction in a manner similar to the NS1 protein of human strains. There was no direct correlation between the IFN-beta induction and replication of avian influenza viruses in human A549 cells. Nevertheless, human cells deficient in the type I IFN system showed enhanced replication of the avian viruses studied, implying that the human type I IFN response limits avian influenza viruses and can contribute to host range restriction.
A Hayman; S Comely; A Lackenby; L C S Hartgroves; S Goodbourn; J W McCauley; W S Barclay
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2006-12-20
Journal Detail:
Title:  Journal of virology     Volume:  81     ISSN:  0022-538X     ISO Abbreviation:  J. Virol.     Publication Date:  2007 Mar 
Date Detail:
Created Date:  2007-02-12     Completed Date:  2007-03-27     Revised Date:  2014-02-19    
Medline Journal Info:
Nlm Unique ID:  0113724     Medline TA:  J Virol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  2318-27     Citation Subset:  IM    
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MeSH Terms
Amino Acid Sequence
Cell Line
Cercopithecus aethiops
Gene Expression
Immunity, Innate
Influenza A virus / genetics,  immunology,  pathogenicity*
Interferon Type I / antagonists & inhibitors,  biosynthesis*,  genetics
Molecular Sequence Data
Sequence Homology, Amino Acid
Vero Cells
Viral Nonstructural Proteins / genetics,  immunology,  physiology*
Virus Replication
Grant Support
MC_U117585868//Medical Research Council; //Wellcome Trust
Reg. No./Substance:
0/INS1 protein, influenza virus; 0/Interferon Type I; 0/Viral Nonstructural Proteins

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