Document Detail

NS-3, a TRH analog, reverses repeated ECS-induced deficits in water maze performance in the rat.
MedLine Citation:
PMID:  8208765     Owner:  NLM     Status:  MEDLINE    
Rats given five consecutive daily electroconvulsive shock (ECS) treatments and trained to run in the Morris water maze, starting three days posttreatment, showed deficits in learning and memory functions. Treatment before each training session with the thyrotropin-releasing hormone (TRH) analog NS-3 [(CG-3703), (3R),(6R)-6-methyl-5-oxo-3-thiomorphorinyl-l-histidyl-l-prolinamid e tetrahydrate] reversed these behavioral deficits. The possible use of TRH and its analogs as therapeutic treatment for the cognitive dysfunctions resulting from electroconvulsive shock treatment for depression and the possible involvement of central cholinergic systems in the cognitive dysfunctions are discussed.
A Khan; H Lai; Y Ukai; M H Mirolo
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Pharmacology, biochemistry, and behavior     Volume:  47     ISSN:  0091-3057     ISO Abbreviation:  Pharmacol. Biochem. Behav.     Publication Date:  1994 Mar 
Date Detail:
Created Date:  1994-07-11     Completed Date:  1994-07-11     Revised Date:  2005-11-17    
Medline Journal Info:
Nlm Unique ID:  0367050     Medline TA:  Pharmacol Biochem Behav     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  477-81     Citation Subset:  IM    
Department of Psychiatry and Behavioral Sciences, University of Washington School of Medicine, Seattle 98195.
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MeSH Terms
Learning / drug effects*
Memory / drug effects
Rats, Sprague-Dawley
Thyrotropin-Releasing Hormone / analogs & derivatives*,  pharmacology
Reg. No./Substance:
24305-27-9/Thyrotropin-Releasing Hormone; 62305-91-3/montirelin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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