Document Detail


NR2C and NR2D subunits of NMDA receptors in frog and turtle retina.
MedLine Citation:
PMID:  22386206     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Glutamate NMDA (N-methyl-d-aspartate) receptors are widely distributed in the central nervous system where they are involved in cognitive processes, motor control and many other functions. They are also well studied in the retina, which may be regarded as a biological model of the nervous system. However, little is known about NR2C and NR2D subunits of NMDA receptors, which have some specific features as compared to other subunits. Consequently the aim of the present study was to investigate their distribution in frog (Rana ridibunda) and turtle (Emys orbicularis) retinas which possess mixed and cone types of retina respectively. The experiments were performed using an indirect immunofluorescence method. Four antibodies directed to NR2C and NR2D subunits of NMDA receptor, as well as three antibodies directed to different splice variants of NR1 subunit, which is known to be obligatory for proper functioning of the receptor, were applied. All antibodies caused well expressed labeling in frog and turtle retinas. The NR2C and NR2D subunits were localized in glial Müller cells, while the NR1 subunit had both neuronal and glial localization. Our results show that glial NMDA receptors differ from neuronal ones in their subunit composition. The functional significance of the NMDA receptors and their NR2C and NR2D subunits, in particular for the neuron-glia interactions, is discussed.
Authors:
Lily Alexandrova Vitanova
Related Documents :
22029386 - New serotonin 5-ht1a receptor agonists with neuroprotective effect against ischemic cel...
8130176 - Gabaa membrane currents are insensitive to extracellular acidification in cultured sens...
8961186 - Synaptic nmda receptors in developing mouse hippocampal neurones: functional properties...
16368816 - Actions of norepinephrine and isoflurane on inhibitory synaptic transmission in adult r...
3368046 - Acetylcholine receptor synthesis rate and levels of receptor subunit messenger rnas in ...
22029386 - New serotonin 5-ht1a receptor agonists with neuroprotective effect against ischemic cel...
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-3-1
Journal Detail:
Title:  Acta histochemica     Volume:  -     ISSN:  1618-0372     ISO Abbreviation:  -     Publication Date:  2012 Mar 
Date Detail:
Created Date:  2012-3-5     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0370320     Medline TA:  Acta Histochem     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
Copyright © 2012 Elsevier GmbH. All rights reserved.
Affiliation:
Department of Physiology, Medical University, 1 G. Sofiisky Street, Sofia 1431, Bulgaria.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Electrochemical characterization of Self-assembled Monolayers (SAMs) of silanes on indium tin oxide ...
Next Document:  New monolithic chromatographic supports for macromolecules immobilization: Challenges and opportunit...