Document Detail


NPY receptor subtype specification for behavioral adaptive strategies during limited food access.
MedLine Citation:
PMID:  21923762     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
The neuropeptide Y (NPY) system in the brain regulates a wide variety of behavioral, metabolic and hormonal homeostatic processes required for energy balance control. During times of limited food availability, NPY promotes behavioral hyperactivity necessary to explore and prepare for novel food resources. As NPY can act via 5 different receptor subtypes, we investigated the path through which NPY affects different behavioral components relevant for adaptation to such conditions. We tested NPY Y1 and Y2 receptor knockout mice and their wildtype littermate controls in a daily scheduled limited food access paradigm with unlimited access to running wheel. Here we show that NPY Y1 receptor deficient mice lack the expression of appetitive behavior and that NPY Y2 receptors control the level of hyperactive behavior under these conditions. Thus, receptor specificity determines the differential expression of NPY-mediated behavioral adaptations to overcome a negative energy status.
Authors:
Eneda Pjetri; Roger A Adan; Herbert Herzog; Ria de Haas; Hugo Oppelaar; Henk A Spierenburg; Berend Olivier; Martien J Kas
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2011-9-16
Journal Detail:
Title:  Genes, brain, and behavior     Volume:  -     ISSN:  1601-183X     ISO Abbreviation:  -     Publication Date:  2011 Sep 
Date Detail:
Created Date:  2011-9-19     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101129617     Medline TA:  Genes Brain Behav     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
Journal compilation © 2011 Blackwell Publishing Ltd/International Behavioural and Neural Genetic Society.
Affiliation:
Rudolf Magnus Institute of Neuroscience, Department of Neuroscience and Pharmacology, University Medical Centre Utrecht, Utrecht, the Netherlands The Neurobiology Research Program, The Garvan Institute of Medical Research, Darlinghurst, New South Wales, Australia Utrecht Institute for Pharmaceutical Sciences, Department of Psychopharmacology, Faculty of Science, Utrecht University, Utrecht, the Netherlands Department of Psychiatry, Yale University School of Medicine, New Haven, USA.
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