| NPY mediates the feeding elicited by muscimol injections into the nucleus accumbens shell. | |
| | |
MedLine Citation:
|
PMID: 15570176 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
Injections of muscimol into the nucleus accumbens shell (AcbSh) induce large increases in food intake in satiated rats and also activate neurons in a number of feeding-related brain regions, including NPY-containing neurons in the arcuate hypothalamic nucleus and cells in the paraventricular hypothalamic nucleus. This suggests that the NPY system may participate in the expression of AcbSh-mediated feeding behavior. Therefore, we examined the effects of intraventricular administration of the Y1 receptor antagonist 1229U91 or the Y5 receptor antagonist L-152,804 on AcbSh-mediated food intake. Intra-AcbSh muscimol elicited a large increase in food intake which was potently suppressed by blocking either central Y1 or Y5 receptors. Our results suggest that the AcbSh influences food intake, in part, through the release of NPY. |
| | |
Authors:
|
Thomas R Stratford; David Wirtshafter |
Related Documents
:
|
17618856 - Adiponectin stimulates amp-activated protein kinase in the hypothalamus and increases f... 15189116 - The critical role of the melanocortin system in the control of energy balance. 19796256 - Role of orexins in the hypothalamic-pituitary-ovarian relationships. 11179606 - Orexin-a immunoreactive neurons in the rat hypothalamus do not contain neuronal nitric ... 15506186 - Investigations into the vertical distribution of pcdds and mineralogy in three ball cla... 21647946 - Landscape-level patterns of mercury contamination of fish in north texas, usa. |
Publication Detail:
|
Type: Comparative Study; Journal Article; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
|
Title: Neuroreport Volume: 15 ISSN: 0959-4965 ISO Abbreviation: Neuroreport Publication Date: 2004 Dec |
Date Detail:
|
Created Date: 2004-11-30 Completed Date: 2005-05-16 Revised Date: 2007-11-14 |
Medline Journal Info:
|
Nlm Unique ID: 9100935 Medline TA: Neuroreport Country: England |
Other Details:
|
Languages: eng Pagination: 2673-6 Citation Subset: IM |
Affiliation:
|
Laboratory of Integrative Neuroscience and Department of Psychology (m/c 285), University of Illinois at Chicago, 1007 W. Harrison Street, Chicago, IL 60607, USA. ratdoc@uic.edu |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Analysis of Variance Animals Behavior, Animal Cyclohexanes / pharmacology Dose-Response Relationship, Drug Drug Administration Routes Drug Interactions Eating / drug effects* GABA Agonists / pharmacology* Male Muscimol / pharmacology* Neuropeptide Y / physiology* Nucleus Accumbens / drug effects* Peptides, Cyclic / pharmacology Rats Rats, Sprague-Dawley Receptors, Neuropeptide Y / antagonists & inhibitors Xanthenes / pharmacology |
| Grant Support | |
ID/Acronym/Agency:
|
NS 33992/NS/NINDS NIH HHS |
| Chemical | |
Reg. No./Substance:
|
0/1229U91; 0/Cyclohexanes; 0/GABA Agonists; 0/L 152804; 0/Neuropeptide Y; 0/Peptides, Cyclic; 0/Receptors, Neuropeptide Y; 0/Xanthenes; 2763-96-4/Muscimol |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Effects of co-activation on cortical organization and discrimination performance.
Next Document: A novel neurotrophic peptide: APP63-73.