Document Detail


NPY and galanin in a hibernator: hypothalamic gene expression and effects on feeding.
MedLine Citation:
PMID:  7693306     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Neuropeptides such as neuropeptide Y (NPY) and galanin may play a role in regulating the pronounced seasonal changes in food intake shown by golden-mantled ground squirrels (Spermophilus saturatus). We used in situ hybridization histochemistry to localize the expression of NPY and galanin mRNA in the hypothalamus of normally feeding animals. NPY mRNA was abundantly expressed in the arcuate nucleus, while galanin mRNA was concentrated in both the arcuate nucleus and the dorsomedial nuclei. When NPY (0.1, 0.5, 2, and 8 micrograms) or galanin (0.1, 0.5, 2, and 8 micrograms) were injected into the third cerebral ventricle, food intake was significantly and dose-dependently increased over the subsequent 30 min. NPY stimulated significant increases in food intake for up to 2 h whereas galanin's effect did not extend beyond 30 min. Our results suggest that hibernating and nonhibernating rodents share common neural substrates for the regulation of food intake. Seasonal modulation of these neural pathways may contribute to annual cycles of food intake in hibernating mammals.
Authors:
T Boswell; R D Richardson; M W Schwartz; D A D'Alessio; S C Woods; A J Sipols; D G Baskin; G J Kenagy
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Brain research bulletin     Volume:  32     ISSN:  0361-9230     ISO Abbreviation:  Brain Res. Bull.     Publication Date:  1993  
Date Detail:
Created Date:  1993-12-03     Completed Date:  1993-12-03     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  7605818     Medline TA:  Brain Res Bull     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  379-84     Citation Subset:  IM    
Affiliation:
Department of Zoology, University of Washington, Seattle 98195.
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MeSH Terms
Descriptor/Qualifier:
Analysis of Variance
Animals
Arcuate Nucleus / metabolism
Base Sequence
Cerebral Ventricles / drug effects,  physiology*
Dorsomedial Hypothalamic Nucleus / metabolism
Eating / physiology*
Feeding Behavior / drug effects*
Galanin
Gene Expression*
Hibernation / physiology*
Hypothalamus / cytology,  metabolism*
In Situ Hybridization
Molecular Sequence Data
Neuropeptide Y / administration & dosage,  biosynthesis*,  pharmacology*
Neuropeptides / biosynthesis*
Oligonucleotide Probes
Peptide Biosynthesis*
RNA, Messenger / biosynthesis
Sciuridae / physiology*
Grant Support
ID/Acronym/Agency:
DK17047/DK/NIDDK NIH HHS; DK17844/DK/NIDDK NIH HHS
Chemical
Reg. No./Substance:
0/Neuropeptide Y; 0/Neuropeptides; 0/Oligonucleotide Probes; 0/RNA, Messenger; 88813-36-9/Galanin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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